Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 225-004-1 | CAS number: 4602-84-0
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 January 2015 - 27 April 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- 2006
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 113 (Screening Test for Thermal Stability and Stability in Air)
- Version / remarks:
- 1981
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- dynamic method
- Key result
- Temp.:
- 20 °C
- Vapour pressure:
- 0.13 hPa
- Temp.:
- 25 °C
- Vapour pressure:
- 0.17 hPa
- Temp.:
- 50 °C
- Vapour pressure:
- 0.58 hPa
- Conclusions:
- The vapour pressures at 20, 25 and 50°C were calculated to be 0.13, 0.17 and 0.58 hPa, respectively.
- Executive summary:
At 20, 25 and 50°C, the vapour pressures were calculated to be 0.13, 0.17 and 0.58 hPa, respectively, as determined by vapour-liquid equilibrium. The study is considered to be reliable without restriction (Klimisch 1) as it was conducted according to OECD 104 and 113, EU A.4. GLP-compliance is not reported.
Reference
Table 1. Results of the vapour-liquid equilibrium (VLE)
| Run number | Temperature (°C) |
Vapour pressure (hPa) |
Remark |
1 |
146.4 |
18.6 |
measured up |
2 |
171.0 |
29.9 |
measured up |
3 |
178.2 |
35.0 |
measured up |
| 4 | 182.5 | 39.8 | measured up |
| 5 | 188.0 | 44.8 | measured up |
| 6 | 191.0 | 49.8 | measured up |
| 7 | 196.5 | 58.4 | measured up |
| 8 | 189.8 | 48.0 | measured down |
| 9 | 181.8 | 36.9 | measured down |
| 10 | 164.1 | 21.9 | measured down |
From the measured data points of the vapour pressure curve the constants A, B and C of the Antoine equation was derived by regression (Microsoft Excel) of the data points:
A = 8.0768
B = -2040.18
C = 273.15
Table 2. Calculated vapour pressure values for 20, 25 and 50 °C
Temperature (°C) |
Vapour pressure (hPa) |
20 |
0.13 |
| 25 | 0.17 |
| 50 | 0.58 |
Description of key information
The vapour pressure at 20, 25 and 50°C was calculated to be 0.13, 0.17 and 0.58 hPa, respectively, as determined by vapour-liquid equilibrium.
Key value for chemical safety assessment
- Vapour pressure:
- 0.13 hPa
- at the temperature of:
- 20 °C
Additional information
The study is considered to be reliable without restriction (Klimisch 1) as it was conducted according to OECD 104 and 113, EU A.4. GLP-compliance is not reported.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
