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Diss Factsheets
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EC number: 204-198-1 | CAS number: 117-57-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- THE PRODUCT WAS ADDED TO THE TEST WATER WITHOUT ANY PRETREATMENT; SUBSEQUENTLY THE FISH WERE PLACED THE AQUARIUM CONTENTS WERE COLORED AND CLOUDY AND UNDISSOLVED TEST SUBSTANCE WAS VISIBLE
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: DIN 38 412 "TESTVERFAHREN MIT WASSERORGANISMEN (GRUPPE L). ALLCEMEINE HINWEISE ZUR PLANUNG, DURCHFUEHRUNG UND AUSWERTUNG BIOLOGISCHER TESTVERFAHREN (L1)-- UND ‹BESTIMMUNG DER WIRKUNG VON WASSERINHALTSSTOFFEN AUF FISCHE - FISCHTEST (L15)--, JUNE 1982,
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-hydroxy-2-methylquinoline-4-carboxylic acid
- EC Number:
- 204-198-1
- EC Name:
- 3-hydroxy-2-methylquinoline-4-carboxylic acid
- Cas Number:
- 117-57-7
- Molecular formula:
- C11H9NO3
- IUPAC Name:
- 3-hydroxy-2-methylquinoline-4-carboxylic acid
- Test material form:
- solid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Test concentrations: 2150 mg/L, 4640 mg/L, 10000 mg/L
Test organisms
- Test organisms (species):
- Leuciscus idus
- Details on test organisms:
- SUPPLIER: FISCHZUCHT PAUL EGGERS
D-W2354 HOHENWESTEDT, FRG
BODY LENGTH: 5.3 CM (RANGE: 4.2 - 6.0)
BODY WEICHT: 1.7 G (RANGE: 0.8 - 2.4)
Study design
- Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 2.5 MMOL/L,
RATIO Ca/Mg IONS 4 :1
RATIO Na/K IONS :10 :1 - Test temperature:
- 21-22°C
- pH:
- 7.7 to 7.9 in control
5.9 to 6.3 in treated solutions - Dissolved oxygen:
- 7.5 to 9.1 mg/L in control
8.1 to 8.6 mg/L in treated solutions - Salinity:
- 294.0 MG/L CACL2 .2 H20
123.3 mg/L MgSO4 .7 H20
63.0 mg/L NaHCO3
5.5 mg/L KCL - Details on test conditions:
- PHOTOPERIOD: 16 HOURS LIGHT AND 8 HOURS DARK
- Reference substance (positive control):
- yes
- Remarks:
- CHLOROACETAMIDE LC 50 AFTER 48 H: ABOUT 32 mg/L
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 9 535 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The study is considered invalid as the pre-treatment of the test substance consisted of a simple adding of test substance to the water. No filtration occured and fish were kept in aquaria with turbid water.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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