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EC number: 201-066-5 | CAS number: 77-89-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1959
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Toxicology of the Citric Acid Esters: Tributyl Citrate, Acetyl Tributyl Citrate, Triethyl Citrate, and Acetyl Triethyl Citrate
- Author:
- Finkelstein M & Gold H
- Year:
- 1 959
- Bibliographic source:
- Toxicol Applied Pharmacol 1, 283 - 298
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 959
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Repeated exposure via diet.
- GLP compliance:
- no
Test material
- Reference substance name:
- Triethyl O-acetylcitrate
- EC Number:
- 201-066-5
- EC Name:
- Triethyl O-acetylcitrate
- Cas Number:
- 77-89-4
- Molecular formula:
- C14H22O8
- IUPAC Name:
- triethyl 2-acetoxypropane-1,2,3-tricarboxylate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: not reported
- Age at study initiation: 21 days
- Weight at study initiation: not reported
- Fasting period before study: not reported
- Housing: not reported
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: not reported
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- DIET PREPARATION
- Rate of preparation of diet (frequency): not detailed
- Mixing appropriate amounts with (Type of food): Basal laboratory rat diet - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- Six weeks, plus 2 weeks recovery
- Frequency of treatment:
- Continually, ad libitum
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0.5 other: % in diet
- Remarks:
- approximate daily consumption of 1 g/kg in the early part of the experiment
- Dose / conc.:
- 1 other: % in diet
- Remarks:
- approximate daily consumption of 2 g/kg in the early part of the experiment
- Dose / conc.:
- 2 other: % in diet
- Remarks:
- approximate daily consumption of 4 g/kg in the early part of the experiment
- No. of animals per sex per dose:
- 4 animals per sex per dose
- Control animals:
- yes, concurrent no treatment
Examinations
- Observations and examinations performed and frequency:
- Body weights were measured initially and weekly until study completion
CAGE SIDE OBSERVATIONS: Performed, as clinical signs were described
DETAILED CLINICAL OBSERVATIONS: No data
BODY WEIGHT: Yes
- Time schedule for examinations: weekly
- Sacrifice and pathology:
- Not reported
- Other examinations:
- Not reported
- Statistics:
- No statistics were performed, because the sample size was very small
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- effects observed, treatment-related
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Details on results:
- None of the three test concentrations of Acetyl Triethyl Citrate had any effect on growth and the test substance did not induce toxicity. Ingestion of Acetyl TriethylCitrate also had no effect on red blood cell count, white blood cell count, or differential blood count.
Effect levels
- Dose descriptor:
- NOEL
- Effect level:
- >= 2 other: % in diet
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: no effects observed
- Remarks on result:
- not determinable due to absence of adverse toxic effects
Target system / organ toxicity
- Critical effects observed:
- no
Applicant's summary and conclusion
- Conclusions:
- The NOEL was at a dietary concentration of 2%, which is equal to 4000 mg/kg.
- Executive summary:
ATEC was fed to rats for 6 weeks as dietary admixture at a 0.5, 1 and 2% level. Control animals received plane diet without test item. No effects were observed at dietary levels up to 2%.
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