Registration Dossier
Registration Dossier
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EC number: 820-605-0 | CAS number: 30881-23-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 3-[(4-hydroxy-3-methoxyphenyl)methyl]pentane-2,4-dione
- EC Number:
- 820-605-0
- Cas Number:
- 30881-23-3
- Molecular formula:
- C13H16O4
- IUPAC Name:
- 3-[(4-hydroxy-3-methoxyphenyl)methyl]pentane-2,4-dione
1
Test system
- Vehicle:
- other: corn oil
- Controls:
- yes, concurrent vehicle
- yes, concurrent positive control
- yes, concurrent negative control
- Amount / concentration applied:
- 750 μL, 20% in corm oil
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vitro
Results
- Irritation parameter:
- in vitro irritation score
- Value:
- 4.93
- Vehicle controls validity:
- valid
- Remarks:
- 0.69
- Negative controls validity:
- valid
- Remarks:
- 0.55
- Positive controls validity:
- valid
- Remarks:
- 113.07
Applicant's summary and conclusion
- Interpretation of results:
- other: no prediction can be made
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