Manganese bis(phosphinate)

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data from peer reviewed journal

Data source

Reference

Reference Type:

secondary source

Title:

Acute oral toxicity study of test material.

Author:

U.S. National Library of Medicine

Year:

2018

Bibliographic source:

ChemIDplusA TOXNET Database, 2017

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

other: As mentioned below

Principles of method if other than guideline:

Acute oral toxicity study of test material was performed in mouse.

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Manganese sulphate

EC Number:

232-089-9

EC Name:

Manganese sulphate

Cas Number:

7785-87-7

Molecular formula:

H2O4S.Mn

IUPAC Name:

manganese sulphate anhydrous

Details on test material:

- Name of test material (as cited in study report):manganese sulphate anhydrous
- Molecular formula :H2O4S.Mn
- Molecular weight :151.0g/mole
- Substance type:Inorganic

Test animals

Species:

mouse

Strain:

Swiss

Sex:

male

Details on test animals or test system and environmental conditions:

Details on test animal
TEST ANIMALS
- Source: No data available
- Age at study initiation: No data available
- Weight at study initiation:20-22g
- Fasting period before study: No data available
- Housing: polycarbonate cages
- Diet (e.g. ad libitum): The animals were fed Gold Mohur Hind Lever diet ad libitum.
- Water (e.g. ad libitum): water ad libitum.

- Acclimation period:

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 24± 0.5°C
- Humidity (%):No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): a 12 h dark and 12 h
light cycle.

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

other: de-ionized triple glass distilled water

Details on oral exposure:

The test material were dissolved in de-ionized triple glass distilled water

Doses:

2330mg/kg bw

No. of animals per sex per dose:

Total :10
0 mg/kg bw: 5
2330mg/kg bw:5

Control animals:

yes

Details on study design:

The gross behavioural changes were recorded at 30, 60, 120 and 240 min using method of Irwin (1959).10 The changes in rectal temperature were recorded by using the thermocouple probes on Digital precision thermometer-DU-3S (ELLAB, DENMARK).

Statistics:

No data available

Results and discussion

Preliminary study:

No data available

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

2 330 mg/kg bw

Based on:

test mat.

Remarks on result:

other: 50% mortality was observed in treated mouse at 2330mg/kg bw.

Mortality:

50% mortality was observed in treated mouse at 2330mg/kg bw.

Clinical signs:

other: Behavioral changes like somnolence (general depressed activity), convulsions or effect on seizure threshold were observed

Gross pathology:

no data available

Other findings:

no data available

Applicant's summary and conclusion

Interpretation of results:

other: Not classified

Conclusions:

LD50 was considered to be 2330mg/kg bw. When mouse were treated with test material orally.

Executive summary:

In acute oral toxicity study, maleSwiss strain Albino mice were treated withtest material in dose concentration 2330mg/kg bw orally.The test material were dissolved inde-ionized triple glass distilled water. Each group consisted of 5 animals.50% mortality was observed in treated mouse at 2330 mg/kg bw.Behavioral changes like somnolence (general depressed activity) and convulsions or effect on seizure threshold were observed in treated mice.Therefore, LD50 was considered to be 2330mg/kg bw. When mouse were treated with test material orally.