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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 257-775-5 | CAS number: 52238-69-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Direct Yellow 142 is a orange organic powder. It is characterized by an appreciable molecular weight and carries ionic charges.
The substance is expected to possess a low potential for bioaccumulation, based on the screening evaluation taken into account the experimental log Pow. Due to the molecular mass greater than 700 and due to the steric hindrance, the possible passage of gill membranes or cell membranes of respiratory organs is expected to be negligible.
Direct Yellow 142 is not toxic/harmful for short-term exposures and it is not skin/eye irritating. It is not able to cause skin sensitization. No genotoxic activity has been observed in specific experiments performed. The subacute repeated dose toxicity study and the screening on reproductive toxicity did not evidence any reason of concern.
There is no specific studies or specific literature data on toxicokinetics and metabolism, thus available information about the substance and analogues has been taken into account, avoiding further tests.
Because of the physical state and the physicochemical properties of Direct Yellow 142, inhalation is not an appropriate route of exposure; in addition, the substance dermal absorption is expected to be low.
During the acute oral toxicity experiments, the treatment did not produce changes detected in health condition. During the subacute oral tests, no significant effect due to the treatment with Similar Substance 01 and Similar Substance 02 were recorded, up to the appreciable high dose of 1000 mg/kg bw/day; one of the explanation may be the limited absorption of the substance, due to the high molecular weight and considering that it is very water soluble
In addition, the sulphonation degree is expected to contribute to increased solubility and to decreased absorption.
Although on the basis of the available information a definitive conclusion about possible metabolism and metabolites cannot be traced, neither from qualitative, either from rate point of view, the absence of significant effects directly attributable to the test item administration lets to suppose that only few rates of substance can be absorbed or that it can be metabolised into a easily eliminable compound(s). In any case, processes of bioactivation, which may increase the substance toxicity, can be excluded.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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