2-anilinoethanol

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Non-GLP non-guideline study, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1967

Report date:

1967

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

According to BASF-internal method: 5 or 10 mice per sex per dose were treated by injection into the peritoneal cavity with prepartations of the test substance. Documentation of clinical signs was performed over the 7-day study period. On the basis of the observed lethality, the LD50 was estimated. Necropsy was performed at the end of the study.

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-anilinoethanol

EC Number:

204-588-1

EC Name:

2-anilinoethanol

Cas Number:

122-98-5

Molecular formula:

C8H11NO

IUPAC Name:

2-(phenylamino)ethan-1-ol

Details on test material:

- Name of the test substance used in the study report: Mono-oxaethylanilin
- Physical state: liquid

Test animals

Species:

mouse

Strain:

other: Kisslegg mice

Sex:

male/female

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

other: Aqueous emulsion with Traganth

Details on exposure:

Test concentrations used were 1, 2, 4 or 20% (v/v); aqueous emulsion with Traganth

Doses:

0.125, 0.16, 0.2, 0.25, 0.32, 1.6 mL/kg, corresponding to: 136.25, 174.4, 218, 272.5, 348.8, 1744 mg/kg

No. of animals per sex per dose:

- 136.25, 174.4, 218, 348.8, 1744 mg/kg: 5
- 272.5 mg/kg: 10

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 327 mg/kg bw

Based on:

test mat.

Remarks on result:

other: original value: ca. 0.3 mL/kg

Mortality:

- No mortality observed in animals exposed to 125 mL/kg
- 2 out of 10 animals died exposed to 160 mL/kg
- 3 out of 10 animals died exposed to 200 mL/kg
- 2 out of 20 animals died exposed to 250 mL/kg
- 6 out of 10 animals died exposed to 320 mL/kg
- All animals exposed to 1600 mL/kg died

Clinical signs:

Immediately after injection apathy, lying in abdominal and lateral position, irregular breathing, size flanks reduced, sticky eyes, muscle twitching

Gross pathology:

In all animals who were necropsied after 7 days adhesions between liver ans stomach and liver capsule fibrosis were observed.