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EC number: 236-599-2 | CAS number: 13446-49-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation, other
- Remarks:
- in vivo study
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990-07-16 to 1990- 07-30
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, conducted and documented in accordance with GLP principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- adopted 24 February 1987
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- The study report states that the study was conducted in compliance with Good Laboratory Practice Standards, e.g. by the United Kingdom Compliance Programme, Department of Health & Social Security 1986 and subsequent revision, Department of Health, 1989.
Test material
- Reference substance name:
- Diammonium dimolybdate
- EC Number:
- 248-517-2
- EC Name:
- Diammonium dimolybdate
- Cas Number:
- 27546-07-2
- IUPAC Name:
- Diammonium dimolybdate
- Details on test material:
- - Name of test material: ammonium dimolybdate
- Physical state: white crystalline powder
- Analytical purity: 56.43% molybdenum, corresponding to > 99.9% ammonium dimolybdate
- Impurities (identity and concentrations): all < 0.01%
- Purity test date: 6 June 1990
- Stability under test conditions: not determined
- Storage condition of test material: at ambient temperature
No further significant information on test material was stated.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Age at study initiation: approximately 12 to 13 weeks
- Weight at study initiation: weight range 2.8 to 3.1 kg
- Housing: The rabbits were individually housed in metal cages with perforated floors.
- Diet: free access to SDS Standard Rabbit Diet
- Water: free access to tap water
- Acclimation period: The rabbits were acclimated to the laboratory environment, but the acclimatisation period was not stated.
ENVIRONMENTAL CONDITIONS
- Temperature: maintained at approximately 19 °C
- relative humidity: maintained at 30 - 70 %
- Air exchanges: maintained at approximately 19 air changes per hour
- Photoperiod (hrs dark / hrs light): 12 hrs/12hrs
No further significant information on test animals were given.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The contralateral eye remained untreated and served as a control.
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: A 100 mg amount of Ammonium molybdate, the weight occupying a volume of 0.1 ml, was placed into the lower everted lid of one eye of each animal. The eyelids were then gently held together for one second before releasing.
- Concentration (if solution):
VEHICLE: Test substance was administered as supplied by the Sponsor.
No further significant information on amount/concentration applied was stated. - Duration of treatment / exposure:
- not stated
- Observation period (in vivo):
- Examination of the eyes was made after 1 hour and 1, 2, 3, 4 and 7 days after instillation.
- Number of animals or in vitro replicates:
- 6 rabbits
- Details on study design:
- SCORING SYSTEM:
Grading and scoring of the ocular lesions were performed using the prescribed numerical scoring system as follows:
Cornea:
Opacity: degree of density (area most dense taken for reading)
No ulceration or opacity = 0
Scattered or diffuse areas of opacity (other than slight dulling of normal lustre), details of iris clearly visible = 1
Easily discernible translucent areas, details of iris slightly obscured = 2
Nacrous areas, no details of iris visible, size of pupil barely discernible = 3
Opaque cornea, iris not discernible through the opacity = 4
Area of cornea involved:
One quarter (or less) but not zero = 1
Greater than one quarter, but less than half = 2
Greater than half, but less than three quarters = 3
Greater than three quarters, up to whole area = 4
Iris:
Normal = 0
Markedly deepened rugae, congestion, swelling, moderate circumcorneal hyperaemia or injection, any of these or combination of any thereof, iris still reacting to light (sluggish reaction is positive) = 1
No reaction to light, haemorrhage, gross destruction (any or all of these) = 2
Conjunctivae:
Redness (refers to palpebral and bulbar conjunctivae cornea and iris)
Blood vessels normal = 0
Some blood vessels definitely hyperaemic (injected) = 1
Diffuse, crimson colour, individual vessels not easily discernible = 2
Diffuse, beefy red = 3
Chemosis (lids and/or nictitating membranes)
No swelling = 0
Any swelling above normal (includes nictitating membranes) = 1
Obvious swelling with partial eversion of lids = 2
Swelling with lids about half-closed = 3
Swelling with lids more than half-closed = 4
TOOL USED TO ASSESS SCORE: Observation of the eyes was aided by the use of a handheld torch.
OTHER OBSERVATIONS: All animals were observed daily for signs of ill health or toxic signs.
No further significant information was stated.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- other: mean of all 6 animals
- Time point:
- other: 24, 48 and 72h
- Score:
- 0
- Irritation parameter:
- iris score
- Basis:
- other: mean of all six animals
- Time point:
- other: 24, 48 and 72h
- Score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Remarks:
- mean
- Time point:
- other: 24, 48 and 72h
- Score:
- 1.33
- Max. score:
- 2
- Reversibility:
- fully reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Remarks:
- mean
- Time point:
- other: 24, 48 and 72h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Remarks:
- mean
- Time point:
- other: 24, 48 and 72h
- Score:
- 0.67
- Max. score:
- 1
- Reversibility:
- fully reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #4
- Remarks:
- mean
- Time point:
- other: 24, 48 and 72h
- Score:
- 0.33
- Max. score:
- 1
- Reversibility:
- fully reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #5
- Remarks:
- mean
- Time point:
- other: 24, 48 and 72h
- Score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #6
- Remarks:
- mean
- Time point:
- other: 24, 48 and 72h
- Score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Remarks:
- mean
- Time point:
- other: 24, 48 and 72h
- Score:
- 0.33
- Max. score:
- 1
- Reversibility:
- fully reversible
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Remarks:
- mean
- Time point:
- other: 24, 48 and 72h
- Score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Remarks:
- mean
- Time point:
- other: 24, 48 and 72h
- Score:
- 0.33
- Max. score:
- 1
- Reversibility:
- fully reversible
- Irritation parameter:
- chemosis score
- Basis:
- animal #4
- Remarks:
- mean
- Time point:
- other: 24, 48 and 72h
- Score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- animal #5
- Remarks:
- mean
- Time point:
- other: 24, 48 and 72h
- Score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- animal #6
- Remarks:
- mean
- Time point:
- other: 24, 48 and 72h
- Score:
- 0
- Other effects:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Instillation of Ammonium dimolybdate into the rabbit eye elicited transient very slight conjunctival inflammation only.
Ammonium dimolybdate does not require classification as an eye irritant according to directive 67/548/EEC or regulation 1272/2008/EC, respectively. A pdf document including the calculation of mean irritation scores according to both guidelines is attached to this endpoint study record.
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