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EC number: 219-247-2 | CAS number: 2393-23-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- of read across substance
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- WoE report is based on two short term toxicity study of fish for the test chemical :
1 and 2 . This study was designed to assess the toxic effects of the test compound on the Zebra fish (Danio rerio). Test was conducted in compliance with the OECD guideline 203. - Specific details on test material used for the study:
- - Name of test material: 4-Methoxybenzylamine
- IUPAC name: p-anisylamine
- Molecular formula: C8H11NO
- Molecular weight: 137.181 g/mole
- Smiles :O(c1ccc(cc1)CN)C
- Inchl: 1S/C8H11NO/c1-10-8-4-2-7(6-9)3-5-8/h2-5H,6,9H2,1H3
- Substance type: Organic
- Physical state: Liquid (Colorless to pale yellow) - Details on sampling:
- 1.The test substance was soluble in water. Therefore, the test solution was prepared by dissolving 1 g of the test substance in 4 liters of potable water (passed through reverse osmosis system) with continuous stirring for achieving test concentrations of 100 mg/L, respectively.
- Vehicle:
- not specified
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- 1 , 2 :TEST ORGANISM
- Animal species: Zebra fish(Danio rerio)
- Animal breeder/ supplier: Orange City Aquarium, Sitabuldi, Nagpur, MS (India)
- Body length: average: 2.5 cm
- Body weight: 0.162 g (average)
The fishes were kept in a static tank in tap water passed through reverse osmosis system, under natural conditions along with proper feed and aeration.
- Duration of housing: 15 days
- Photoperiod: 16 hours light and 8 hours dark
- Oxygen content: 5.94 (mg/l)
- pH: 5.7
- Water temperature: 30°C
- Mortality (%): During last 14 days 0 mortality was observed
- Diet: Standard brand feed, once daily
- Acclimatization: Fishes, to be used in the study, are kept in the test water for seven days immediately before testing under following conditions:
- Photoperiod: 16 hours light and 8 hours dark
- Temperature range: 23 °C
- pH range: 5.77
- DO range: 5.94 mg/l
- Feeding: Daily once
- Aeration: Continuous - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- 24, 48, 72, 96 hrs
- Hardness:
- 1 - 50 (mg of CaCO3)
2 - 148.5 mg of CaCO3 - Test temperature:
- 22-23°C
- pH:
- 5.7-7.05
- Dissolved oxygen:
- 1 - 5.94(mg/l)
2 - 8.0 mg/l - Nominal and measured concentrations:
- 100 mg/l
- Details on test conditions:
- 1.TEST SYSTEM
- Test vessel: Plastic aquaria
- Type (delete if not applicable): open / closed: No data
- Material, size, headspace, fill volume: Plastic aquaria having the water capacity of 5 liters filled with 4 liters of water with 1 liter of headspace.
- Aeration: Aeration in test vessels was provided 1 day before the start of experiment
- No. of organisms per vessel: 8 fishes
- Withdrawal of food: 1 day before and during exposure
OTHER TEST CONDITIONS
- Photoperiod: 16 hours light and 8 hours dark
- EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Observations (mortality, visible symptoms, pH, Temperature, dissolved oxygen content) were recorded after 24 hours, 48 hours, 72 hours and 96 hours of the start of the experiment.
2.TEST SYSTEM
- Test vessel:The test vessels used were all plastic aquaria having the water capacity of 5liters.
- Material, size, headspace, fill volume: 2 liters
- Aeration: No
- No. of organisms per vessel:8
OTHER TEST CONDITIONS
- Adjustment of pH:No
- Photoperiod:16 hours light and 8 hours dark
TEST CONCENTRATIONS
- Test concentrations: 0,100 mg/l - Reference substance (positive control):
- not specified
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Read across 1
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Read across 2
- Details on results:
- 2.A 96 h study was conducted for on Zebra fish(Danio rerio), at a test concentrations of 100mg/L . The fishes were moving slowly as compared to control.
- Conclusions:
- The test chemical 4-Methoxybenzylamine is not likely to be toxic to fish in concentration > 100 mg/l
- Executive summary:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the short term toxicity of fish of the test chemical 4-Methoxybenzylamine (2393 -23 -9).The studies are as mentioned below:
1.This study was designed to assess the toxic effects of the test compound 4-Methoxy benzyl alcohol on the Zebra fish (Danio rerio). Test was conducted in compliance with the OECD guideline 203. The test substance was soluble in water. Therefore, the test solution was prepared by dissolving 1 g of the test substance in 4 liters of potable water (passed through reverse osmosis system) with continuous stirring for achieving test concentrations of 100 mg/L, respectively.
Test conducted at limit test concentration 100 mg/l and Zebra fishes were exposed to this concentration for 96 hours. Test animal was collected from Orange City Aquarium, Sitabuldi, Nagpur, MS (India). 8 fishes exposed to the test concentration. Aeration in test vessels was provided 1 day before the start of experiment. After the exposure of chemical (mortality, visible symptoms, pH, Temperature, dissolved oxygen content) were recorded after 24 hours, 48 hours, 72 hours and 96 hours of the start of the experiment.
Based on nominal concentrations, experimental median lethal Concentrations [LC-50 (96 h)] for test chemical on Zebra fish (Danio rerio) was determined to be > 100 mg/L by observing the mortality. Thus based on LC50 it can be concluded that the chemical was nontoxic and can be consider to be not classified as per the CLP classification criteria.
2. Fish Acute Toxicity test according to OECD Guideline 203 was conducted for test chemical. The nominal concentration selected for the experiment were 100mg/L and test fish were exposed to these concentration for 96 hours. The median lethal concentration (LC50) for test chemical on Danio rerio in a 96 hours study on the basis of mortality effect was found to be >100 mg/L. Thus, on the basis of this LC50 value and according to CLP criteria for aquatic classification of the substance, it is concluded that the substance, test chemical does not exhibit short term toxicity to fish. LC0 (96 hours) (highest loading at which no mortality was observed) = 100 mg/L .LC50 (96 hours) Experimental = >100 mg/L
Thus, based on the above summarised studies, 4-Methoxybenzylamine and it’s structurally and functionally similar read across substance, it can be concluded that effect concetration value is >100 mg/l. Thus, comparing this value with the criteria of CLP regulation 4-Methoxybenzylamine cannot be classified
for short term toxicity for fish .Hence,based on the data available for the structurally and functionally similarread across, test chemical 4-Methoxybenzylamine is not likely to be toxic atleast in the concentration >100 mg/L .
Reference
Description of key information
Short-term toxicity to fish:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the short term toxicity of fish of the test chemical 4-Methoxybenzylamine (2393 -23 -9).The studies are as mentioned below:
1.This study was designed to assess the toxic effects of the test compound 4-Methoxy benzyl alcohol on the Zebra fish (Danio rerio). Test was conducted in compliance with the OECD guideline 203. The test substance was soluble in water. Therefore, the test solution was prepared by dissolving 1 g of the test substance in 4 liters of potable water (passed through reverse osmosis system) with continuous stirring for achieving test concentrations of 100 mg/L, respectively.
Test conducted at limit test concentration 100 mg/l and Zebra fishes were exposed to this concentration for 96 hours. Test animal was collected from Orange City Aquarium, Sitabuldi, Nagpur, MS (India). 8 fishes exposed to the test concentration. Aeration in test vessels was provided 1 day before the start of experiment. After the exposure of chemical (mortality, visible symptoms, pH, Temperature, dissolved oxygen content) were recorded after 24 hours, 48 hours, 72 hours and 96 hours of the start of the experiment.
Based on nominal concentrations, experimental median lethal Concentrations [LC-50 (96 h)] for test chemical on Zebra fish (Danio rerio) was determined to be > 100 mg/L by observing the mortality. Thus based on LC50 it can be concluded that the chemical was nontoxic and can be consider to be not classified as per the CLP classification criteria.
2.Fish Acute Toxicity test according to OECD Guideline 203 was conducted for test chemical. The nominal concentration selected for the experiment were 100mg/L and test fish were exposed to these concentration for 96 hours. The median lethal concentration (LC50) for test chemical on Danio rerio in a 96 hours study on the basis of mortality effect was found to be >100 mg/L. Thus, on the basis of this LC50 value and according to CLP criteria for aquatic classification of the substance, it is concluded that the substance, test chemical does not exhibit short term toxicity to fish. LC0 (96 hours) (highest loading at which no mortality was observed) = 100 mg/L .LC50 (96 hours) Experimental = >100 mg/L
Thus, based on the above summarised studies, 4-Methoxybenzylamine and it’s structurally and functionally similar read across substance, it can be concluded that effect concetration value is >100 mg/l. Thus, comparing this value with the criteria of CLP regulation 4-Methoxybenzylamine cannot be classified
for short term toxicity for fish .Hence,based on the data available for the structurally and functionally similarread across, test chemical 4-Methoxybenzylamine is not likely to be toxic atleast in the concentration >100 mg/L .
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 100 mg/L
Additional information
Short-term toxicity to fish:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the short term toxicity of fish of the test chemical 4-Methoxybenzylamine (2393 -23 -9).The studies are as mentioned below:
1.This study was designed to assess the toxic effects of the test compound 4-Methoxy benzyl alcohol on the Zebra fish (Danio rerio). Test was conducted in compliance with the OECD guideline 203. The test substance was soluble in water. Therefore, the test solution was prepared by dissolving 1 g of the test substance in 4 liters of potable water (passed through reverse osmosis system) with continuous stirring for achieving test concentrations of 100 mg/L, respectively.
Test conducted at limit test concentration 100 mg/l and Zebra fishes were exposed to this concentration for 96 hours. Test animal was collected from Orange City Aquarium, Sitabuldi, Nagpur, MS (India). 8 fishes exposed to the test concentration. Aeration in test vessels was provided 1 day before the start of experiment. After the exposure of chemical (mortality, visible symptoms, pH, Temperature, dissolved oxygen content) were recorded after 24 hours, 48 hours, 72 hours and 96 hours of the start of the experiment.
Based on nominal concentrations, experimental median lethal Concentrations [LC-50 (96 h)] for test chemical on Zebra fish (Danio rerio) was determined to be > 100 mg/L by observing the mortality. Thus based on LC50 it can be concluded that the chemical was nontoxic and can be consider to be not classified as per the CLP classification criteria.
2.Fish Acute Toxicity test according to OECD Guideline 203 was conducted for test chemical. The nominal concentration selected for the experiment were 100mg/L and test fish were exposed to these concentration for 96 hours. The median lethal concentration (LC50) for test chemical on Danio rerio in a 96 hours study on the basis of mortality effect was found to be >100 mg/L. Thus, on the basis of this LC50 value and according to CLP criteria for aquatic classification of the substance, it is concluded that the substance, test chemical does not exhibit short term toxicity to fish. LC0 (96 hours) (highest loading at which no mortality was observed) = 100 mg/L .LC50 (96 hours) Experimental = >100 mg/L
Thus, based on the above summarised studies, 4-Methoxybenzylamine and it’s structurally and functionally similar read across substance, it can be concluded that effect concetration value is >100 mg/l. Thus, comparing this value with the criteria of CLP regulation 4-Methoxybenzylamine cannot be classified
for short term toxicity for fish .Hence,based on the data available for the structurally and functionally similarread across, test chemical 4-Methoxybenzylamine is not likely to be toxic atleast in the concentration >100 mg/L .
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