Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-969-4 | CAS number: 90-15-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 21 December 2016 to 12 January 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- according to guideline
- Guideline:
- ISO 13320 (Particle size analysis - Laser diffraction methods)
- Qualifier:
- according to guideline
- Guideline:
- other: CIPAC MT 187
- Principles of method if other than guideline:
- Principle of test:
The sample is initially observed using a visual microscope to determine whether sieving of the material is requiered.
The laser diffraction method which determine the mass median aerodynamic diameter (MMAD) needs the generation of a representative test atmospheres using suitable generation equipment and correct sampling techniques.
A method development for the particle size analysis on the material is then undertaken to obtain the correct parameters for the formal analysis. The method development is employed to identify the most appropriate optical properties for the material, the correct dispersant, dispersion pressures and sample compatibility. Once these parameters are obtained the final sample is then analysed using the Malvern Mastersizer 2000 Laser Diffraction Analyser.
This procedure allows the operator to obtain a better understanding of the particle characterisation of the material. This includes, but is not limited to, sample clusters and agglomerations which may provide false values in the formal particle size analysis. In these situations, where the operator can assess how easily these clusters or aggomerations are dispersed, ultrasonics may be employed. Owing to the extremely small quantities of material used in this analysis it should be noted that discrepancies can arise between the lower and upper limits of the particle size and the actual value obtained in the formal particle size analysis. - GLP compliance:
- yes (incl. QA statement)
- Type of method:
- Laser scattering/diffraction
- Type of particle tested:
- primary particle
- Type of distribution:
- volumetric distribution
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: A017 / Batch Number : 7215604684
- Expiration date of the lot/batch: NA
- Purity test date: 09 september 2016
- Purity : 99.1% ±0.1%
- Re-analysis date : NA
- Description : Cream / beige to grey flakes
Relative Density : 1.28 g/cm3 (data taken from SDS)
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: NA
- Stability under test conditions: NA
- Solubility and stability of the test substance in the solvent/vehicle: NA
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: NA
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: no, sample is tested as received.
- Preliminary purification step (if any): no
- Final dilution of a dissolved solid, stock liquid or gel: no
- Final preparation of a solid: no - Mass median aerodynamic diameter:
- >= 264.981 - <= 275.922 µm
- Geometric standard deviation:
- >= 2.041 - <= 2.14
- Remarks on result:
- other: The average Mass Median Aerodynamic diameter is 268.252 µm. Average result is calculated from the entirety of data captured in each run and is not a simple arithmetic mean.
- Key result
- Percentile:
- D10
- Mean:
- ca. 92.293 µm
- St. dev.:
- 2.063
- Key result
- Percentile:
- D50
- Mean:
- ca. 237.103 µm
- St. dev.:
- 3.591
- Key result
- Percentile:
- D90
- Mean:
- ca. 509.337 µm
- St. dev.:
- 3.69
- No.:
- #1
- Size:
- <= 10 µm
- Distribution:
- ca. 1.05 %
- No.:
- #2
- Size:
- <= 50.238 µm
- Distribution:
- ca. 1.79 %
- No.:
- #3
- Size:
- <= 70.963 µm
- Distribution:
- ca. 4.85 %
- No.:
- #4
- Size:
- <= 100 µm
- Distribution:
- ca. 12.19 %
- No.:
- #5
- Size:
- <= 178.25 µm
- Distribution:
- ca. 34.68 %
- No.:
- #6
- Size:
- <= 250 µm
- Distribution:
- ca. 53.05 %
- No.:
- #7
- Size:
- <= 399.052 µm
- Distribution:
- ca. 79.44 %
- No.:
- #8
- Size:
- <= 632.456 µm
- Distribution:
- ca. 96.2 %
- No.:
- #9
- Size:
- <= 900 µm
- Distribution:
- ca. 99.9 %
- No.:
- #10
- Size:
- <= 1 700 µm
- Distribution:
- ca. 100 %
- Conclusions:
- The average mass median aerodynamic diameter of the test item is 268.252 µm.
- Executive summary:
The particle size distribution was determined according to the ISO 13320 (Particle size analysis - Laser diffraction methods) and the GLP.
The results of the particle Diameter are presented below :
Particle size analysis using small volume (wet) module (SVM)
Average (µmeter) Volume weighted mean 272.504 Median (D.50) 237.103 Mode 278..639 MMAD (Mass Median Aerodynamic Diameter) 268.252 10% of material is <
92.293 50% of material is < 237.103 90% of material is < 509.337 volume of sample <10.00 µmeter 1.05% The Coefficient of variations for D50 is less than 3%; D10 and D90 are less than 5%.
Thus repeatability of the characteristic particles in the size distribution are within the acceptable limits as per the ISO 13320-1 test standard.
Reference
Preliminary standard visual observation :
Sample observed to be coarse, medium to fine cream /beige to grey flakes with clusters and some agglomerations.
Observation at 100 x magnification :
The particles appeared to be irregular shaped crystals. The smallest individual particle size was approximately 3 µm and the largest individual siz was approximately 563 µm.
Observation at 400 x magnification :
The sample was observed to be made up of single crystalline particles and agglomerated particles.
method development phase of the analysis trials :
The results of the SVM trials indicates that the most appropriate test and material parameters were :
Module : Small Volume Module
Dispersant : Silicone Oil
Dispersion speed : 2300 rpm
Refractive Index (sample) : 0.000 n
Absorption : 0.0 AU
Analysis Model : General Purpose (Normal)
The results of the formal analysis of the particle size distribution (volume (%) versus particle diameter) are presented above.
Description of key information
The average mass median aerodynamic diameter of the test item is 268.252 µm.
Additional information
The particle size distribution was determined according to the ISO 13320 (Particle size analysis - Laser diffraction methods) and the GLP.
The results of the particle Diameter :
Particle size analysis using small volume (wet) module (SVM) |
Average (µm) |
Volume weighted mean |
272.504 |
Median (D.50) |
237.103 |
Mode |
278..639 |
MMAD (Mass Median Aerodynamic Diameter) |
268.252 |
10% of material is < |
92.293 |
50% of material is < |
237.103 |
90% of material is < |
509.337 |
volume of sample <10.00 µm |
1.05% |
The Coefficient of variations for D50 is less than 3%; D10 and D90 are less than 5%.
Thus repeatability of the characteristic particles in the size distribution are within the acceptable limits as per the ISO 13320-1 test standard.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.