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EC number: 253-930-6 | CAS number: 38436-16-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986-05-13 to 1986-05-16
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- No duplicate plates; no historical data; insufficient detail on S9 preparation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- yes
- Remarks:
- no duplicate plates
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Dichloromethyl(3,3,4,4,5,5,6,6,6-nonafluorohexyl)silane
- EC Number:
- 253-930-6
- EC Name:
- Dichloromethyl(3,3,4,4,5,5,6,6,6-nonafluorohexyl)silane
- Cas Number:
- 38436-16-7
- Molecular formula:
- C7H7Cl2F9Si
- IUPAC Name:
- Dichloro(methyl)(3,3,4,4,5,5,6,6,6-nonafluorohexyl)silane
- Reference substance name:
- [2-(perfluorobutyl)ethyl]dichloro(methyl)silane
- IUPAC Name:
- [2-(perfluorobutyl)ethyl]dichloro(methyl)silane
- Details on test material:
- [2-(perfluorobutyl)ethyl]dichloro(methyl)silane
Constituent 1
Constituent 2
Method
- Target gene:
- histidine operon (Salmonella typhimurium strains); tryptophan operon (E. coli strain)
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and E. coli WP2
- Metabolic activation:
- with and without
- Metabolic activation system:
- Aroclor induced rat liver S9
- Test concentrations with justification for top dose:
- 78.12, 156.25, 312.5, 625, 1250 µg/plate
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: ethanol
- Justification for choice of solvent/vehicle: none given in study report
Controlsopen allclose all
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- Remarks:
- ethanol
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- sodium azide
- Remarks:
- 10 μg/plate; strains TA 100, TA 1535; without metabolic activation
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- Remarks:
- ethanol
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: daunomycin
- Remarks:
- 10 μg/plate; strain TA 98; without metabolic activation
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- Remarks:
- ethanol
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- 4-nitroquinoline-N-oxide
- Remarks:
- 10 μg/plate; strain TA 1537; without metabolic activation
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- Remarks:
- ethanol
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: n-methyl-n-nitro-n-nitrosoguanidine
- Remarks:
- 10 μg/plate; strain WP2; without metabolic activation
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- Remarks:
- ethanol
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: 2-anthramine
- Remarks:
- 10 μg/plate; strains TA 1535, WP2; with metabolic activation
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- Remarks:
- ethanol
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: 2-aminofluorene
- Remarks:
- 10 μg/plate; strains TA 1537, TA-98, TA-100; with metabolic activation
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: in agar (plate incorporation); other: spotted onto surface of agar
ACTIVATION: Aroclor induced rat liver S9; co-factors and concentration in plates not indicated in report
DURATION
- Exposure duration: 72 hours
SELECTION AGENT (mutation assays): histidine (Salmonella strains) or tryptophan (E. coli) deficient agar
NUMBER OF REPLICATIONS: An initial spot test was followed by a plate incorporation assay.
DETERMINATION OF CYTOTOXICITY
- Method: no information
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and E. coli WP2
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- 1250 μg/plate
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not applicable
- Positive controls validity:
- valid
Any other information on results incl. tables
|
TA-1535 |
TA-1537 |
TA-98 |
TA-100 |
WP2 |
|||||
Concentration (μg/plate) |
- MA |
+ MA |
- MA |
+ MA |
- MA |
+ MA |
- MA |
+ MA |
- MA |
+ MA |
Solvent control |
15 |
15 |
5 |
9 |
23 |
23 |
160 |
122 |
28 |
26 |
Positive Control |
559 |
382 |
117 |
212 |
326 |
376 |
671 |
445 |
226 |
246 |
78.12 |
16 |
12 |
5 |
8 |
21 |
23 |
146 |
116 |
30 |
22 |
156.25 |
14 |
13 |
4 |
7 |
20 |
23 |
151 |
128 |
27 |
25 |
312.5 |
17 |
10 |
4 |
10 |
22 |
22 |
130 |
137 |
20 |
27 |
625 |
12 |
11 |
4 |
5 |
19 |
19 |
101 |
114 |
23 |
22 |
1250 |
6 |
7 |
1 |
1 |
12 |
6 |
67 |
72 |
14 |
4 |
Applicant's summary and conclusion
- Conclusions:
- [2-(perfluorobutyl)ethyl]dichloro(methyl)silane has been tested for mutagenicity to bacteria, in a study which was conducted according to a protocol that is similar to OECD 471, and in compliance with GLP (Dow Corning Corporation, 1986). No evidence of a test-substance related increase in the number of revertants was observed with or without metabolic activation in Salmonella typhimurium strains TA 98, TA 100, TA 1535, TA 1537 or E. coli WP2 in the initial spot test for toxicity or the repeat experiment conducted using the plate incorporation method, when tested up to cytotoxic concentrations. Appropriate positive and solvent controls were included and gave the expected results. It is concluded that the test substance is negative for mutagenicity to bacteria under the conditions of the test.
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