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EC number: 235-166-5 | CAS number: 12108-13-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- sub-chronic toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- Not mentioned
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Dermal study investigating the effects of mmt in a gasoline carrier with insufficient study documentation for assessment.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- grey literature
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
- Remarks:
- Study conducted prior to GLP guidelines
- Limit test:
- no
Test material
- Reference substance name:
- Tricarbonyl(methylcyclopentadienyl)manganese
- EC Number:
- 235-166-5
- EC Name:
- Tricarbonyl(methylcyclopentadienyl)manganese
- Cas Number:
- 12108-13-3
- Molecular formula:
- C9H7MnO3
- IUPAC Name:
- tricarbonyl(methyl-η5-cyclopentadienyl)manganese
- Details on test material:
- - Name of test material (as cited in study report): Methylcyclopentadienyl Manganese Tricarbonyl in gasoline
- Physical state: Liquid
- Analytical purity: 98.05%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- other: Gasoline
- Details on exposure:
- The test material was administrated to the animals in either leaded or non-leaded gasoline
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2 ml/kg was applied on the skin of rabbits and rats - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 14 weeks for rabbits and 22 weeks for rats.
- Frequency of treatment:
- Single daily administration, 5 days per week.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 0.4, 2.4 and 16.0 g/L
Basis:
no data
- No. of animals per sex per dose:
- No data
- Control animals:
- no
- Details on study design:
- None.
- Positive control:
- No.
Examinations
- Observations and examinations performed and frequency:
- The animals were observed for signs of illness, skin injury and body weight.
- Sacrifice and pathology:
- No.
- Other examinations:
- None.
- Statistics:
- No.
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Dermal irritation:
- effects observed, treatment-related
- Mortality:
- mortality observed, treatment-related
- Body weight and weight changes:
- effects observed, treatment-related
- Food consumption and compound intake (if feeding study):
- not examined
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- not examined
- Clinical biochemistry findings:
- not examined
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- not examined
- Organ weight findings including organ / body weight ratios:
- not examined
- Gross pathological findings:
- not examined
- Histopathological findings: non-neoplastic:
- not examined
- Histopathological findings: neoplastic:
- not examined
- Details on results:
- RABBITS
Body weight loss and severe local injury at the site of application of the gasoline (leaded and non-leaded) were found. The mortality and local effectsshad no relationship with the concentration of mmt or to the presence of tetraethyl lead in the gasoline.
RATS
Mild skin injury and no signs of ilness. All animals increase their body weight.
Effect levels
- Dose descriptor:
- NOEL
- Effect level:
- 16 other: g/l
- Based on:
- not specified
- Sex:
- male/female
- Basis for effect level:
- other: Body weight
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Table 1 - The average week bw of male rabbits dermally exposed to leaded and non-leaded gasoline containing MMT
Average bw (kg) on the specified week |
Conc. MMT (g/l) |
|||||||
Leaded gasoline |
Non-leaded gasoline |
|||||||
0 |
0.4 |
2.4 |
16.0 |
0 |
0.4 |
2.4 |
16.0 |
|
-1 |
3.98 |
4.21 |
3.96 |
3.94 |
4.14 |
3.86 |
4.21 |
3.94 |
S |
4.06 |
4.41 |
4.04 |
4.00 |
4.27 |
3.96 |
4.20 |
4.00 |
1 |
3.86 |
4.22 |
3.92 |
3.91 |
4.13 |
3.85 |
4.16 |
3.91 |
2 |
3.71* |
3.91 |
3.70 |
3.63 |
3.92 |
3.66 |
3.89* |
3.63* |
3 |
3.43 |
3.67 |
3.55 |
3.58 |
3.74 |
3.68* |
3.80* |
3.58 |
4 |
3.37 |
3.46 |
3.67 |
3.49 |
3.51* |
3.62 |
3.60 |
3.49 |
5 |
3.33 |
3.64* |
3.59 |
3.44 |
3.64 |
3.53* |
3.51 |
3.44 |
6 |
3.32 |
3.61 |
3.65 |
3.46 |
3.56 |
3.57 |
3.58 |
3.46 |
7 |
3.30 |
3.51 |
3.70 |
3.36 |
3.46 |
3.52 |
3.49 |
3.36 |
8 |
3.29 |
3.51 |
3.62 |
3.36 |
3.38 |
3.32 |
3.32 |
3.36 |
9 |
3.23 |
3.48 |
3.54 |
3.39 |
3.22* |
3.56* |
3.35 |
3.39 |
10 |
3.24* |
3.49 |
3.40 |
3.26 |
3.56 |
3.53 |
3.29 |
3.26 |
11 |
3.29 |
3.46 |
3.63 |
3.35 |
3.61 |
3.47 |
3.32 |
3.35* |
12 |
3.28 |
3.44 |
3.60 |
3.41 |
3.53 |
3.37 |
3.30 |
3.41 |
13 |
3.26 |
3.66 |
3.65 |
3.42 |
3.42 |
3.31 |
3.26 |
3.42 |
Table 2 - The average week bw of female rats dermally exposed to leaded and non-leaded gasoline containing MMT
Average bw (kg) on the specified week |
Conc. MMT (g/l) |
|||||||
Leaded gasoline |
Non-leaded gasoline |
|||||||
0 |
0.4 |
2.4 |
16.0 |
0 |
0.4 |
2.4 |
16.0 |
|
Start |
116 |
116 |
119 |
121 |
115 |
112 |
118 |
118 |
1 |
131 |
128 |
133 |
124 |
129 |
126 |
120 |
127 |
2 |
160 |
150 |
155 |
162 |
161 |
161 |
155 |
159 |
3 |
166 |
166 |
168 |
170 |
170 |
172 |
172 |
171 |
4 |
178 |
177 |
179 |
192 |
179 |
188 |
184 |
187 |
5 |
194 |
190 |
189 |
206 |
195 |
204 |
198 |
199 |
6 |
200 |
198 |
194 |
211 |
201 |
208 |
204 |
204 |
7 |
206 |
210 |
214 |
223 |
214 |
219 |
217 |
219 |
8 |
215 |
213 |
207 |
228 |
218 |
221 |
218 |
218 |
9 |
224 |
223 |
221 |
236 |
226 |
237 |
230 |
232 |
10 |
225 |
229 |
221 |
242 |
228 |
237 |
230 |
229 |
11 |
235 |
236 |
228 |
246 |
234 |
243 |
240 |
238 |
12 |
240 |
242 |
232 |
251 |
243 |
248 |
241 |
241 |
13 |
241 |
244 |
236 |
256 |
241 |
250 |
244 |
243 |
14 |
250 |
250 |
241 |
262 |
245 |
256 |
251 |
245 |
15 |
248 |
257 |
246 |
266 |
252 |
262 |
257 |
252 |
16 |
249 |
262 |
241 |
264 |
251 |
261 |
259 |
250 |
17 |
256 |
264 |
246 |
269 |
254 |
267 |
261 |
254 |
18 |
260 |
270 |
251 |
274 |
259 |
269 |
263 |
254 |
19 |
263 |
275 |
249 |
276 |
261 |
273 |
262 |
259 |
20 |
|
|
|
|
|
|
|
|
21 |
266 |
276 |
253 |
283 |
267 |
273 |
273 |
263 |
22 |
271 |
280 |
257 |
283 |
270 |
281 |
275 |
266 |
23 |
270 |
281 |
259 |
284 |
275 |
285 |
274 |
269 |
24 |
277 |
283 |
263 |
292 |
276 |
291 |
282 |
269 |
25 |
276 |
288 |
268 |
293 |
280 |
293 |
282 |
270 |
Table 3 - The average week bw of male rats dermally exposed to leaded and non-leaded gasoline containing MMT
Average bw (kg) on the specified week |
Conc. MMT (g/l) |
|||||||
Leaded gasoline |
Non-leaded gasoline |
|||||||
0 |
0.4 |
2.4 |
16.0 |
0 |
0.4 |
2.4 |
16.0 |
|
Start |
146 |
136 |
149 |
149 |
144 |
136 |
149 |
144 |
1 |
167 |
156 |
171 |
174 |
167 |
154 |
145 |
161 |
2 |
226 |
213 |
206 |
233 |
192 |
212 |
210 |
211 |
3 |
252 |
232 |
243 |
254 |
232 |
234 |
251 |
235 |
4 |
286 |
264 |
274 |
293 |
273 |
268 |
284 |
275 |
5 |
313 |
292 |
305 |
322 |
307 |
289 |
303 |
305 |
6 |
321 |
301 |
313 |
335 |
319 |
300 |
317 |
314 |
7 |
352 |
318 |
336 |
350 |
340 |
315 |
336 |
323 |
8 |
357 |
336 |
358 |
362 |
350 |
330 |
349 |
345 |
9 |
380 |
249 |
369 |
376 |
365 |
346 |
367 |
366 |
10 |
392 |
365 |
380 |
393 |
382 |
363 |
380 |
387 |
11 |
404 |
373 |
396 |
403 |
396 |
379 |
387 |
397 |
12 |
414 |
385 |
409 |
410 |
405 |
382 |
392 |
408 |
13 |
423 |
396 |
416 |
415 |
412 |
394 |
400 |
406 |
14 |
431 |
412 |
429 |
429 |
423 |
407 |
415 |
430 |
15 |
440 |
420 |
439 |
440 |
436 |
414 |
422 |
449 |
16 |
453 |
424 |
441 |
443 |
439 |
423 |
423 |
453 |
17 |
465 |
432 |
457 |
451 |
444 |
426 |
438 |
463 |
18 |
468 |
437 |
467 |
453 |
447 |
437 |
446 |
470 |
19 |
478 |
457 |
472 |
470 |
461 |
446 |
459 |
484 |
20 |
|
|
|
|
|
|
|
|
21 |
487 |
469 |
482 |
486 |
469 |
457 |
465 |
494 |
22 |
495 |
477 |
492 |
496 |
478 |
463 |
475 |
401 |
23 |
507 |
476 |
494 |
495 |
483 |
470 |
481 |
511 |
24 |
507 |
491 |
505 |
504 |
487 |
474 |
487 |
523 |
25 |
524 |
500 |
517 |
519 |
499 |
484 |
494 |
530 |
Applicant's summary and conclusion
- Conclusions:
- Based on the findings, mmt in leaded and non-leaded gasoline did not produced toxic effects in female and male rats or male rabbits in concentrations up to 16 g/l, with a NOAEC being set for 16.0g/l.
- Executive summary:
In a repeat-dose dermal toxicity study performed in the University of Cincinnati, mmt in leaded and non-leaded gasoline was applied to male rabbits and mal and female rats for 5 days per week for 14 weeks (rabbits) and 22 weeks (rats).
The rabbits showed loss in body weight and severe local injury at the site of application of the test material, however these effects were also seen in the controls implying that the findings were related to the gasoline itself rather than mmt. The rats showed mild skin injury and no signs of illness. No mortality was observed and all female and male rats increased their body weight. Based on the findings the NOAEL was derived to be 16.0 g/l for both rabbit and rat.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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