Registration Dossier
Registration Dossier
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EC number: 814-994-6 | CAS number: 123403-95-2
Adsorption / desorption
Administrative data
Link to relevant study record(s)
Description of key information
Adsorption to the solid soil phase is not expected.
Key value for chemical safety assessment
- Koc at 20 °C:
- 19.3
Additional information
QSAR-disclaimer
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of 3-(1-ethoxyethyl)-5-methyloxazolidin-2-one (EE-MOX) (CAS 123403-95-2) (Q)SAR results were used for the estimation of the adsorption potential. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
Therefore, further experimental studies on the adsorption potential are not provided.
Assessment
In accordance with column 2 of REACH Annexes VIII and IX, the study does not need to be conducted if based on the physicochemical properties the substance can be expected to have a low potential for adsorption (e.g. the substance has a low octanol water partition coefficient), or the substance and its relevant degradation products decompose rapidly. 3-(1 -Ethoxyethyl)-5-methyloxazolidin-2-one (EE-MOX) (CAS 123403-95-2) has an estimated log Kow of 1.36 (calculated with KOWWIN model v1.68, EPI Suite v4.11).
However, in order to assess the adsorption potential of the substance, the Koc value was estimated using QSAR models. According to the MCI method of the KOCWIN v2.00 modHwever, ule of EPI Suite v4.11. EE-MOX (CAS 123403-95-2) has a Koc of 19.3 L/kg (log Koc = 1.29). The estimation of the MCI module was selected as key value as it is more reliable than the log Kow method of KOCWIN v2.00, which estimates the KOC based on the n-octanol/water partition coefficient (estimated log Kow = 1.36; EPI Suite v4.11, 2018). The latter method resulted also in a Koc of 28.9 L/kg (log Koc = 1.46); the substance is within the applicability domain of the estimation models.
In conclusion, adsorption to the solid soil phase is not expected.
[LogKoc: 1.29]
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