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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 212-042-9 | CAS number: 754-05-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- Episuite is a well known QSAR software package that is widely used and accepted by both industry and regulatory authorities.
Trimethylvinylsilane is considered to be inside the applicability domain of the EpiSuite WSKOW model since the following criteria are fulfilled (as described in the model's manual):
- The molecular weight of trimethylvinylsilane is within the molecular weight range of the training set
- Trimethylvinylsilane is within the log Kow range of the training set
- All functional groups present in trimethylvinylsilane are represented in the training set and have a fragment coefficient available
Data source
Reference
- Reference Type:
- other: QSAR
- Title:
- WSKOWWIN v.1.41
- Author:
- EPA’s Office of Pollution Prevention Toxics and Syracuse Research Corporation.
- Year:
- 2 000
- Bibliographic source:
- http://www.epa.gov/opptintr/exposure/pubs/episuite.htm
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- QSAR calculation based on the "fragment constant" methodology.
- GLP compliance:
- no
- Type of method:
- calculation method (fragments)
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Trimethylvinylsilane
- EC Number:
- 212-042-9
- EC Name:
- Trimethylvinylsilane
- Cas Number:
- 754-05-2
- Molecular formula:
- C5H12Si
- IUPAC Name:
- trimethylvinylsilane
Constituent 1
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- 3.07
- Remarks on result:
- other: Note: Temperature and pH not applicable as it concerns a QSAR calculation.
Applicant's summary and conclusion
- Conclusions:
- Log Kow: 3.07
The partition coefficient was calculated by means of EpiSuite's WSKOW model. - Executive summary:
The partition coefficient was retrieved from EpiSuite's WSKOW model and the Log Kow found to be 3.07.
Trimethylvinylsilane is considered to be inside the applicability domain of the EpiSuite WSKOW model since the following criteria are fulfilled:
- The molecular weight of trimethylvinylsilane is within the molecular weight range of the training set.
- Trimethylvinylsilane is within the log Kow range of the training set.
- All functional groups present in trimethylvinylsilane are represented in the training set and have a fragment coefficient available.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.