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Diss Factsheets
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EC number: 203-930-7 | CAS number: 112-04-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
No studies were available to assess the skin sensitisation potential of the test substance, however, data are available for the structural analogue substance triethoxy(methyl)silane (CAS 2031-67-6).
GPMT according to OECD TG 406: not sensitising
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
No studies were available to assess the skin sensitisation potential of dimethoxydimethylsilane (CAS 1112-39-6), however, data are available for the structural analogue substance triethoxy(methyl)silane (CAS 2031 -67 -6).
Details on read across justifications can be found in the attached justification in the respective target entry and in the overall justification for grouping of substances attached in IUCLID Section 13.
Studies were chosen as key when the available study was of relevance and of sufficient quality for classification, labelling and for risk assessment.
In a key guinea pig maximisation study conducted in compliance with GLP and according to OECD TG 406, the structural analogue substance triethoxy(methyl) silane was found to be a non-sensitiser. The sensitisation index was calculated to be 0% for the test group following challenge and rechallenge. A group of ten male and ten female guinea pigs was dosed with multiple intradermal injections on day 0 following a topical application on day 7 in order to investigate sensitisation potential of triethoxy(methyl) silane. The topical induction consisted of a 48 hour occluded dermal exposure to 0.5 ml of the test substance in a 50% (v/v) solution in sterile codex liquid paraffin. Eleven days after topical induction, challenge dosing for detection of sensitisation was performed. For challenge dosing, an essentially non-irritating concentration (10% (v/v)) of the test material was applied under occlusion for 24 hours. The test material vehicle, sterile codex liquid paraffin, was also found to be non-sensitising under the conditions of this study (Hazelton France, 1992b).
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
No data available.
Justification for classification or non-classification
The available data on skin sensitisation of the structural analogue substance, triethoxymethylsilane, do not meet the criteria for classification according to Regulation (EC) 1272/2008 or Directive 67/548/EEC, and are therefore conclusive but not sufficient for classification of the registered substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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