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Diss Factsheets
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EC number: 219-676-5 | CAS number: 2495-39-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: In principle according to OECD 403, however analytical determination of the atmosphere concentration was not performed; the exposure time was 8h; method and results are poorly described in the report (however raw data are available)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- analytical determination, exposure time 8 h
- GLP compliance:
- no
- Test type:
- other: inhalation risk test
Test material
- Reference substance name:
- Sodium prop-2-enesulphonate
- EC Number:
- 219-676-5
- EC Name:
- Sodium prop-2-enesulphonate
- Cas Number:
- 2495-39-8
- Molecular formula:
- C3H6O3S.Na
- IUPAC Name:
- sodium prop-2-ene-1-sulfonate
- Details on test material:
- - Name of test-item: Golpanol SC 9269 = Golpanol ALS
- Purity: 25 % in aqua dest.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Mean weight at study initiation: 238 g (male), 181,3 g (female)
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure chamber volume: 200 L air/h
TEST ATMOSPHERE
- Brief description of analytical method used: Inhalation of a vapour-saturated atmosphere at 20°C. For saturation air was disposed through a 5 cm thick product layer. The calculated vapour saturation for the a. i. is 0.00002 µg/L.
VEHICLE
- Composition of vehicle (if applicable): air - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- Concentrations:
- Concentration was stated to be 4.71 mg/L calculated reweighing of the product column after exposure. Due to the very low vapour pressure ( 3e-09 hPa at 25°C) / vapour saturation (0.00002 µg/L) of the a. i. it is assumed that this substance loss is mainly based on loss of water.
- No. of animals per sex per dose:
- 6
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: Weighing was done on day 0 and day 7. No informations about observation times.
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: IHT
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Remarks on result:
- other: Mortality: 0/12 animals died after exposure to a saturated vapour atmosphere.
- Mortality:
- 0/12 died
- Clinical signs:
- other: Strong mucosa irritation, eyelid closure on the day of exposure. The first day after exposure there were no abnormalities detected anymore.
- Body weight:
- The mean body weights of the animals were in the normal range throughout the study period.
- Gross pathology:
- No abnormalities detected.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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