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EC number: 208-914-3 | CAS number: 546-89-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Lithium acetate dihydrate
- Cas Number:
- 6108-17-4
- Molecular formula:
- C2H7LiO4
- IUPAC Name:
- Lithium acetate dihydrate
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Lot/batch No.of test material: Reference No.: 434-01A; - FMC-T#: 1562
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage: Room temperature
- Stability: Stable for a minimum of 30 days
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories
- Age at study initiation: Adult
- Weight at study initiation: 200-300 g
- Housing: Individually housed in stainless steel, suspended cages containing DACB indirect bedding.
- Diet: Purina Rodent Chow 5001 (pellets), ad libitum
- Water: Tap water, ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: 20 - 20.6 °C
- Humidity: 51 - 56 %
- Photoperiod: 12-hour fluorescent light/dark cycle
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- TEST SITE
- Area of exposure: From the Scapula to the pelvic region.
- % coverage: At least 10 % of the body surface
- Type of wrap if used: Gauze pad was secured with hypoallergenic tape and was covered with an elastic, plastic-lined bandage.
REMOVAL OF TEST SUBSTANCE
- Washing: Test sites were rinsed with water
- Time after start of exposure: 24 h
VEHICLE
- Amount(s) applied: 0.50 mL tap water - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: Observations for toxicity were conducted 0.5, 1, 2, 3, 4 and 6 hours post-dosing, and daily thereafter. Dermal irritation were recorded on days 1, 3, 7 and 14. Body weights were recorded weekly.
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths were noted
- Clinical signs:
- All rats remained healthy during the study.
- Body weight:
- Immediately prior to dosing, body weights ranged from 223-266 g. All but one rat gained weight by day 14 of the study; this rat lost weight through day 7, then regained weight to return to its' pre-dosing weight.
- Gross pathology:
- No gross internal lesions were observed in any animal during necropsy.
- Other findings:
- Local irritation: The only irritation noted during the study was erythema in one female on study day 1.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The dermal LD50 of the test material is greater than 2000 mg/kg.
- Executive summary:
The acute dermal toxicity was assessed equivalent or similar to OECD guideline 402. Lithium acetate dihydrate was topically applied to five Sprague-Dawley rats per sex at a dosage level of 2000 mg/kg. The test material was in contact with the skin under an occlusive wrap for 24 hours. Observations for toxicity were conducted 0.5, 1, 2, 3, 4 and 6 hours post-dosing, and daily thereafter for 14 days. Dermal irritation was recorded in day 1, 3, 7 and 14. Body weights were recorded weekly. Gross necropsies were performed on all animals. No death were noted. All rats remained healthy during the study. All but one rat gained weight by day 14 of the study; this rat lost weight through day 7, then regained weight to return to its' pre-dosing weight. The only dermal irritation noted was erythema in one female on day 1. No gross lesions were revealed during necropsy. The dermal LD50 of the test item is greater than 2000 mg/kg.
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