Registration Dossier
Registration Dossier
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EC number: 233-343-1 | CAS number: 10124-56-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Justification for type of information:
- A scientific review.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Final Report on the Safety Assessment of Sodium Metaphosphate, Sodium Trimetaphosphate, and Sodium Hexametaphosphate
- Author:
- Reviewed by the Cosmetic Ingredient Review Expert Panel.
- Year:
- 2 001
- Bibliographic source:
- International Journal of Toxicology, p 75-89.
Materials and methods
- Principles of method if other than guideline:
- No information on the method.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium metaphosphate
- EC Number:
- 233-343-1
- EC Name:
- Sodium metaphosphate
- Cas Number:
- 10124-56-8
- Molecular formula:
- Na6O18P6
- IUPAC Name:
- hexasodium 2,4,6,8,10,12-hexaoxocyclohexaphosphoxane-2,4,6,8,10,12-hexakis(olate)
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 700 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: LD50=3.7 +/-0.17 g/kg
Applicant's summary and conclusion
- Conclusions:
- In adult CD-1 mice the acute oral LD50 of Sodium Hexametaphosphate was 3.7+/-0.17 g/kg.
- Executive summary:
In adult CD-1 mice the acute oral LD50 of Sodium Hexametaphosphate was 3.7+/-0.17 g/kg.
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