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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer reviewed journal.

Data source

Reference
Reference Type:
publication
Title:
Fragrance raw materials monographs: 4-(p-methoxyphenyl) butan-2-one
Author:
D. L. J. Opdyke
Year:
1974
Bibliographic source:
Food and Cosmetics Toxicology. 12, 929, 1974

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
48-hr closed patch test was done to evaluate irritation effect of 4-(p-methoxyphenyl) butan-2-one in human subjects.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
4-(4-methoxyphenyl)butan-2-one
Cas Number:
104-20-1
Molecular formula:
C11H14O2
IUPAC Name:
4-(4-methoxyphenyl)butan-2-one
Details on test material:
IUPAC: 4-(p-methoxyphenyl)butan-2-one
commen name: anisyl acetone
Molecular formula:C11H14O2
Molecular weight : 178.23 g/mole
Substance type: Organic
InChI :1S/C11H14O2/c1-9(12)3-4-10-5-7-11(13-2)8-6-10/h5-8H,3-4H2,1-2H3
Smiles :c1(ccc(OC)cc1)CCC(C)=O
Specific details on test material used for the study:
IUPAC: 4-(p-methoxyphenyl)butan-2-one
commen name: anisyl acetone
Molecular formula:C11H14O2
Molecular weight : 178.23 g/mole
Substance type: Organic
InChI :1S/C11H14O2/c1-9(12)3-4-10-5-7-11(13-2)8-6-10/h5-8H,3-4H2,1-2H3
Smiles :c1(ccc(OC)cc1)CCC(C)=O
physical property: colourless oily liquid

Test animals

Species:
other: human
Strain:
not specified
Details on test animals or test system and environmental conditions:
No data available

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
other: petrolatum
Controls:
not specified
Amount / concentration applied:
5% in petrolatum
Duration of treatment / exposure:
48 hrs
Observation period:
48 hrs
Number of animals:
no data
Details on study design:
no data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
48 h
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No indication of any skin reaction

Applicant's summary and conclusion

Interpretation of results:
other: Not irritant
Conclusions:
The substance 4-(p-methoxyphenyl) butan-2-one produced no skin reaction when applied on human skin. 4-(p-methoxyphenyl) butan-2-one was considered to be not irritant to human skin
Executive summary:

4-(p-methoxyphenyl) butan-2-one was used as a test material to evaluate its skin irritation potential .

 4-(p-methoxyphenyl) butan-2-one was used in the concentration of 5% in petrolatum for 48hrs in a closed patch test on human subjects.

 The substance 4-(p-methoxyphenyl) butan-2-one produced no skin reaction when applied on human skin.

 4-(p-methoxyphenyl) butan-2-one was considered to be not irritant to human skin.