Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 233-701-7 | CAS number: 10319-14-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- other: read across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2014
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- 3-hydroxy-2-(3-hydroxy-2-quinolyl)-1H-inden-1-one
- EC Number:
- 241-753-7
- EC Name:
- 3-hydroxy-2-(3-hydroxy-2-quinolyl)-1H-inden-1-one
- Cas Number:
- 17772-51-9
- Molecular formula:
- C18H11NO3
- IUPAC Name:
- 3-hydroxy-2-(3-hydroxyquinolin-2-yl)-1H-inden-1-one
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- other: Mice, CBA/CaOlaHsd
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- propylene glycol
- Concentration:
- A solubility experiment was performed according to the recommendations given by OECD 429. The highest test item concentration, which can be technically used, was a 25% suspension in propylene glycol. Vortexing of the test item was used to formulate the test item.
Thus, the test item in the main study was assayed at 5, 10, and 25% (w/w). The highest concentration tested was the highest level that could be achieved whilst avoiding systemic toxicity and excessive local skin irritation as confirmed in the pre-experiment. - No. of animals per dose:
- 5
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: see Remark
- Remarks:
- Test item concentration Mean DPM per animal (2 lymph nodes) a) SD S.I. Vehicle Control Group (PG) 1113.5 321.3 1.00 5% substance 6273.1 857.0 5.63 10% substance 6225.9 1228.1 5.59 25% substance 5079.3 1439.8 4.56
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: see Remark
- Remarks:
- Calculation and Results of Individual Data Vehicle: PG Test item concentration DPM values measured DPM-BG per animal (2 lymph nodes) a) S.I.b) % Group no. Animal no. --- --- BG I 17 --- --- --- --- BG II 20 --- --- 0 1 1 889 870.5 --- 0 1 2 977 958.5 --- 0 1 3 1153 1134.5 --- 0 1 4 1680 1661.5 --- 0 1 5 961 942.5 --- 5 2 6 6124 6105.5 5.5 5 2 7 5798 5779.5 5.2 5 2 8# 7775 7756.5 7.0 5 2 9 5628 5609.5 5.0 5 2 10 6133 6114.5 5.5 10 3 11 4900 4881.5 4.4 10 3 12 6416 6397.5 5.7 10 3 13 5278 5259.5 4.7 10 3 14 6616 6597.5 5.9 10 3 15 8012 7993.5 7.2 25 4 16 3566 3547.5 3.2 25 4 17 7283 7264.5 6.5 25 4 18 5680 5661.5 5.1 25 4 19 4296 4277.5 3.8 25 4 20 4664 4645.5 4.2 # = Outlier as detected by Dean-Dixon- and Grubb’s Test. The value in question (animal no. 8) was not excluded from the calculations, since exclusion of the outlier did not change the overall result. 1 = Control Group 2-4 = Test Group a) = values corrected for mean background value (BGI and BGII) b) = Stimulation Indices relative to the mean of the control group (Group 1)
Any other information on results incl. tables
Viability / Mortality
No deaths occurred during the study period.
Clinical Signs
The animals did not show any signs of local skin irritation during the course of the study and no cases of mortality were observed. On day 1, one animal (no. 14), treated with the test item concentration of 10%, showed a bulging eye (right side). The other animals of that test group and the animals treated with 5 and 25% test item concentration did not show any signs of systemic toxicity. Redness of the ear skin could not be observed, due to the colour of the test item.
Body Weights
The body weight of the animals, recorded prior to the first application and prior to treatment with 3HTdR, was within the range commonly recorded for animals of this strain and age.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (indication of skin sensitising potential) based on GHS criteria
- Executive summary:
In the study the test substance was assessed for its possible skin sensitising potential.
For this purpose a local lymph node assay was performed using test item concentrations of 5, 10, and 25% (w/w).
The animals did not show any signs of local skin irritation during the course of the study and no cases of mortality were observed. On day 1, one animal (no. 14), treated with the test item concentration of 10%, showed a bulging eye (right side). The other animals of that test group and the animals treated with 5 and 25% test item concentration did not show any signs of systemic toxicity. Redness of the ear skin could not be observed, due to the colour of the test item.
In this study Stimulation Indices (S.I.) of 5.63, 5.59, and 4.56 were determined with the test item at concentrations of 5, 10, and 25% (w/w) in PG, respectively.
The test item was found to be a skin sensitiser.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)