Registration Dossier
Registration Dossier
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EC number: 204-671-2 | CAS number: 124-02-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- Diallylamine [124-02-7]: Review of Toxicological Literature
- Author:
- US National Toxicology Program
- Year:
- 1 997
- Bibliographic source:
- US National Toxicology Program
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 0.1 mL applied to 1cm2 area
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Diallylamine
- EC Number:
- 204-671-2
- EC Name:
- Diallylamine
- Cas Number:
- 124-02-7
- Molecular formula:
- C6H11N
- IUPAC Name:
- diallylamine
Constituent 1
- Specific details on test material used for the study:
- Purity not provided.
Test animals
- Species:
- rat
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- rat strain and age not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.1 mL applied to 1 cm2 area of shaved abdominal skin.
- Duration of treatment / exposure:
- Single application
- Observation period:
- Not provided
- Number of animals:
- Not provided
Results and discussion
In vivo
Results
- Remarks on result:
- other: Severe necrosis and death
- Remarks:
- This was a published study not performed according to a guideline. Without the current guideline format, it has not been possible to fully complete this table.
- Irritant / corrosive response data:
- Exposure caused severe necrosis and death, but the incidence of mortality was not provided.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- Exposure caused severe necrosis and death.
- Executive summary:
In rats (strain and age not provided), application of 0.1 mL of diallylamine to a 1 cm2 area of shaved abdominal skin caused severe necrosis and death.
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