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EC number: 255-490-0 | CAS number: 41672-81-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Radiolabelling:
- no
- Test temperature:
- HPLC was used to estimate the adsorption coefficient of trans-1-(1-oxohexadecyl)-4-[(1-oxohexadecyl)oxyl]-L-proline in soil and in sewage sludge.
Analytical column: Zorbax CN 4.6 mm * 250 mm - 5 µm
(Guard column: Zorbax CN 4.6 mm * 12.5 mm - 5 µm)
Mobile phase: methanol/0.01M citrate buffer pH 6.0 (55%/45% v/v)
Wave lenght: 210 nm
Temperature: 30°C
Flow rate: 1 mL/min - Details on study design: HPLC method:
- Measured HPLC retention data were obtained for 11 reference items (acetanilide, atrazine, monuron, 2,5-dichloroaniline, linuron, naphthalene, benzoic acid phenylester, 1,2,3 trichlorobenzene, fenthion, phenanthrene and DDT). Based on these data, a calibration graph of Log k' versus log Koc was established to correlate the measured HPLC retention data of the test item with its adsorption coefficients (Koc) for soil and sewage sludge .
The capcity factors k' were calculated according to the following equation:
k' = (tR-t0)/t0
where:
tR: HPLC retention time in minutes
t0: HPLC dead time in minutes (determined with formamide)
The test item was prepared at a concentration of 1000 mg/L in three replicates.The reference items have been injected before and after the reference items to confirm that retention times had not drifted. - Type:
- log Koc
- Value:
- < 1.25
- Remarks on result:
- other: Estimation by HPLC for soil
- Type:
- log Koc
- Value:
- < 1.46
- Remarks on result:
- other: Estimation by HPLC for sewage sludge
- Details on results (HPLC method):
- The retention times obtained for the three replicates of the test item were below the lowest retention time obtained for the reference items.
- Validity criteria fulfilled:
- yes
- Conclusions:
- In the conditions of this HPLC test, the log Koc values of trans-1-(1-oxohexadecyl)-4-[(1-oxohexadecyl)oxyl]-L-proline for soil and sewage sluge were estimated to be < 1.25 and < 1.46 respectively.
- Executive summary:
The adsorption coefficients (Koc) on soil and on sewage sludge of trans-1-(1-oxohexadecyl)-4-[(1-oxohexadecyl)oxyl]-L-proline were estimated by a HPLC in accordance with OECD guideline 121.
Measured HPLC retention data were obtained for 11 reference items (acetanilide, atrazine, monuron, 2,5 dichloroaniline, linuron, naphathalene, benzoic acid phenylester, 1,2,3 trichlorobenzene, fenthion, phenanthrene and DDT). Based on these data, a calibration graph was established to correlate the measured HPLC retention data of the test item with its adsorption coefficients (Koc) for soil and sewage sludge .
The retention times obtained for the three replicates of the test item were below the lowest retention time obtained for the reference items.
In the conditions of this HPLC test, the log Koc values of trans-1-(1-oxohexadecyl)-4-[(1-oxohexadecyl)oxyl]-L-proline for soil and sewage sluge were estimated to be < 1.25 and < 1.46 respectively.
Reference
Description of key information
Key value for chemical safety assessment
- Koc at 20 °C:
- 28.84
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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