Registration Dossier
Registration Dossier
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EC number: 943-980-3 | CAS number: -
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
In the reproductive toxicity studies, the oral administration of a C12-C14 alkyl polyglucosides to rats produced no fertility effects, therefore the NOAEL for this endpoint was set at 1000 mg/kg bw/day.
Short description of key information:
On the basis of the available data, "Sulfonation products of
(esterification products of C9-11 (branched and linear) alkyl-(mono-,
di- and tri-) glycosides with maleic anhydride) with disodium sulfite"
does not produce fertility effects.
Justification for selection of Effect on fertility via oral route:
Experimental study with reliability score 1
Effects on developmental toxicity
Description of key information
On the basis of the available data, " Sodium salt of esterification products of C10-C16 (even numbered) alkylpolyglycosides with citric acid" does not produce developmental effects.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- chronic
- Species:
- rat
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
In the developmental toxicity study, the oral administration of a C10-C14 alkyl glucoside at doses of 0, 100, 300 and 1000 mg/kg bw/day to rats produced no developmental effects, therefore the NOAEL for this endpoint was set at 1000 mg/kg bw/day.
Justification for selection of Effect on developmental
toxicity: via oral route:
The study refers to a member of the group of alkyl polyglucosides,
and "Sulfonation products of (esterification products of C9-11 (branched
and linear) alkyl-(mono-, di- and tri-) glycosides with maleic
anhydride) with disodium sulfite" pertains to this group.
Justification for classification or non-classification
In the set of reproductive toxicity studies, the oral administration of a C12-C14 alkyl polyglucosides and a C10-C14 alkyl glucoside to rats produced no fertility nor developmental effects; the NOAELs for both endpoints were set at 1000 mg/kg bw/day. As no effects were observed, no C&L for reproductive toxicity is required.
Classification: not required
Signal word: none
Hazard statement: none
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
