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EC number: 217-442-7 | CAS number: 1852-16-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 June 2006 to 13 October 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- N-(butoxymethyl)acrylamide
- EC Number:
- 217-442-7
- EC Name:
- N-(butoxymethyl)acrylamide
- Cas Number:
- 1852-16-0
- Molecular formula:
- C8H15NO2
- IUPAC Name:
- N-(butoxymethyl)prop-2-enamide
- Test material form:
- liquid
- Details on test material:
- - Physical state: Clear liquid
- Storage conditions of test material: Room temperature and humidity. Avoid prolonged storage above 100 °F.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: The pre-test body weight range was 209 - 230 g
- Age at study initiation: Approximately 8 weeks
- Fasting period before study: 16 - 20 hours prior to dosing
- Housing: Animals were housed 1 per cage in suspended wire mesh cages. Bedding was placed beneath the cages and changed at least three times/week.
- Diet: Freely available
- Water: Freely available at all times
- Acclimation period: At least three days
ENVIRONMENTAL CONDITIONS
- Temperature: Not reported, the room was temperature controlled
- Photoperiod: 12 hour light / dark cycle
IN-LIFE DATES:
- From: 27 June 2006
- 10 July 2006
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: The test material was used as received. The dose was based on the sample weight as calculated from the specific gravity.
MAXIMUM DOSE VOLUME APPLIED: 0.24 cc - Doses:
- 1000 mg/kg
- No. of animals per sex per dose:
- Five males
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: Animals were observed 1, 4 and 24 hours post-dose for mortality, toxicity and pharmacological effects. Mortality was recorded once daily thereafter for six days.
- Necropsy of survivors performed: No. All animals were humanely sacrificed using CO2 following the study termination.
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 2 animals died during the test period; the first within 24 hours of administration, the second on Day 2.
- Clinical signs:
- other: Pre-death observations included lethargy, wetness and red staining of the nose/mouth area, negative righting reflex, convulsions, spasms, tremors, unkempt appearance, few faeces, ataxia and wetness of the anogenital area. Instances of lethargy, wetness an
Any other information on results incl. tables
Table 1: Dose Volume and Body Weight
Animal No. |
Sex |
Dose Volume (cc) |
Body weight (g) |
|
Day 0 |
Day7 |
|||
1 |
Male |
0.24 |
230 |
299 |
2 |
Male |
0.22 |
216 |
N/A |
3 |
Male |
0.22 |
209 |
267 |
4 |
Male |
0.23 |
217 |
N/A |
5 |
Male |
0.23 |
221 |
280 |
Mean |
219 |
282 |
||
S.D. |
7.7 |
16.1 |
||
Number |
5 |
3 |
N/A = Not applicable – Animal died before observation period
Table 2: Systemic Observations
Time Period |
Animal No. / Sex |
||||
1/M |
2/M |
3/M |
4/M |
5/M |
|
1 hour |
B |
B |
B, R, T |
B, R |
B, R |
4 hours |
B |
B, 1 |
B, R, I |
B, R, I |
B, R, T, I |
24 hours |
|
1, 2, K, B, I, P, O, 3, X, E |
1 |
Z (204 G) |
1, R, B, 3, X |
Day 2 |
|
1, 2, R, K, I, P, O, X, E, Z (193 G) |
|
|
1, R, X |
Day 3 |
|
|
|
|
2, R |
Day 4 |
|
|
|
|
|
Day 5 |
|
|
|
|
|
Day 6 |
|
|
|
|
|
Day 7 |
|
|
|
|
|
No entry indicates that the animal appeared normal at that observation period.
B = Lethargy
E = Ataxia
I = Convulsion
K = Negative righting reflex
O = Tremors
P = Spasm
R = Anogenital area wet
T = Anogenital area soiled
X = Few faeces
Z = Dead
1= Nose/mouth area stained red
2 = Nose/mouth area wet
3 = Unkempt appearance
Applicant's summary and conclusion
- Interpretation of results:
- other: Category 4 in accordance with EU criteria
- Conclusions:
- Based on the results of this test, the LD50 of the test material was > 1000 mg/kg bw.
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