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EC number: 814-345-7 | CAS number: 2003244-43-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The study was conducted between 08 March 2016 and 29 April 2016.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- The study is considered to be a reliability 1 as it has been conducted according to OECD Test Guideline 105 using the flask method and in compliance with GLP.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 27 July 1995
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Specific details on test material used for the study:
- Identification: ES421 Pinyl Nitrile
SOURCE OF TEST MATERIAL
- Appearance/physical state: white solid
- Source and lot/batch No.of test material: SM15077102
- Expiration date of the lot/batch: 22 July 2016
- Purity: 98.08%
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: approximately 4 °C, in the dark - Key result
- Water solubility:
- 8.38 mg/L
- Temp.:
- 20 °C
- pH:
- 6.2
- Details on results:
- Preliminary test
The preliminary estimate of water solubility was 2.4 x 10-3 g/L at 20.0 °C.
Definitive test
The mean peak areas relating to the standard and sample solutions are shown under 'Any other information on results incl. tables'.
The concentration (g/L) of test item in the sample solutions are shown under 'Any other information on results incl. tables'.
Validation
The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 5 to 100 mg/L. This was satisfactory with a first order correlation coefficient of >0.9999 being obtained. Recovery of analysis of the sample procedure was assessed and proved adequate for the test. At a nominal concentration of 2.5 mg/L, a mean percentage recovery of 96.5% was obtained (n = 5, range 95.8 to 98.4%). Concentrations have not been corrected for recovery of analysis. - Conclusions:
- The water solubility of the test item, ES421 Pinyl Nitrile, has been determined to be 8.38 x 10-3 g/L of solution at 20.0 ± 0.5 °C.
- Executive summary:
The water solubility of the test substance, ES421 Pinyl Nitrile, was 8.38 x 10-3g/L of solution at 20.0 ± 0.5 °C, using a flask method designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
Reference
Definitive test
The
mean peak areas relating to the standard and sample solutions:
Solution |
Mean Peak Area |
Standard solution, 25.2 mg/L |
3.7189 x 106 |
Standard solution, 25.2 mg/L |
3.7572 x 106 |
Standard solution matrix blank |
none detected |
Sample solution matrix blank |
none detected |
Sample solution 1, analysis replicate A |
1.2615 x 107 |
Sample solution 1, analysis replicate B |
1.2643 x 107 |
Sample solution 2, analysis replicate A |
1.2409 x 107 |
Sample solution 2, analysis replicate B |
1.2349 x 107 |
Sample solution 3, analysis replicate A |
1.2280 x 107 |
Sample solution 3, analysis replicate B |
1.2421 x 107 |
The concentration (g/L) of test item in the sample solutions
Sample Number |
Time shaken at 30 °C (hours) |
Time equilibrated at 20 °C (hours) |
Concentration (g/L) |
Solution pH |
1 |
24 |
24 |
8.50 x 10-3 |
6.2 |
2 |
48 |
24 |
8.33 x 10-3 |
6.2 |
3 |
72 |
24 |
8.31 x 10-3 |
6.2 |
Mean concentration: 8.38 x 10-3 g/L at 20.0 ± 0.5 ºC
Range: 8.31 x 10-3 to 8.50 x 10-3 g/L
Standard
Deviation: 1.03 x 10-4
Description of key information
The water solubility ofthe test substance, ES421 Pinyl Nitrile, was8.38 x 10-3g/L of solution at 20.0 ± 0.5 °C, using a flask method designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing ofChemicals, 27 July 1995.
Key value for chemical safety assessment
- Water solubility:
- 8.38 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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