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EC number: 628-863-4 | CAS number: 1219458-14-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Bioaccumulation potential
No measured Bio-Concentration Factor for fish is available for N-(3-aminopropyl)-N'-C16-18 (evennumbered), C18 unsaturated alkyl -propane-1,3-diamine. Standard OECD 305 tests are technically very complicated with substances which are strongly sorbing and rapidly biodegradable. The bioavailable fraction of these substances is quickly degraded and a chronic exposure to a significant concentration is therefore unlikely. The substances are thus either sorbed or biodegraded and are therefore not expected to pose a risk via accumulation in the food chain through bioaccumulation in aquatic or terrestrial organisms.
Based on the available fate information and the structural similarity of the substances, a low bioaccumulation potential is expected for Triamine T under environmental conditions. In the absence of measured BCF values the bioaccumulation potential of a substance can be estimated using QSARS like BCFBAF (US EPA 2017). For non-polar narcotics there is a common understanding that the bioaccumulation potential can be estimated using the observed log Kow of the substance (Gobas & Arnot, 2003; Bysshe, 1982). A weighted mean measured log Kow of -0.3 (Slow stirring at pH 6) is available for a structurally strongly related substance (Amines, N-(3- aminopropyl)-N’-[3-(C18 and C18-unsatd. alkyl amino)propyl] trimethylenedi and amines, N-(3-aminopropyl)-N’-(C18 and C18-unsatd. alkyl)trimethylenedi- (Tetramine O, EC 701-369-7) which results in a BCF of 3.2 L/kg (BCFBAF v 3.01, assuming no metabolism). This low calculated BCF is considered to be also realistic for Triamine T as the fraction of bioavailable unprotonated amine will be very low in the environment. The fraction unprotonated amines at pH 7 is with a pKa of 10.8 (for the primary alkyl group in the structure) less than 0.1% (Beelen, 1998). It should be noted however that these low log Kow values were measured at pH 6. When calculating the log Kow or BCF of the non-protonated amines much higher values are predicted by the BCFBAF model (version 3.01) in EPI suite™ (version 4.11).
In vitro biotransformation by rainbow trout hepatic subcellulair fraction has been observed for primary alkyl amines (Perdu-Durand 2006; Bernhard et al., 2006)) and alkyl propane-1,3 -diamines (Nouryon, internal report). It is therefore likely that also alkyl dipropylene triamines and alkyl tripropylene tetramines are rapidly biotransformed in fish.
BCFBAF Program (v3.01) Results:
==============================
SMILES : CCCCCCCCCCCCCCCCCCNCCCNCCCN
CHEM : C18:0 dipropylenetriamine (non-protonated!)
MOL FOR: C24 H53 N3
MOL WT : 383.71
--------------------------------- BCFBAF v3.01 ------------------------------
Summary Results:
Log BCF (regression-based estimate): 3.20 (BCF = 1.59e+003 L/kg wet-wt)
Biotransformation Half-Life (days) : 77.7 (normalized to 10 g fish)
BCF calculation of using BCFBAF v3.01 |
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Triamine T | EC 628-863-4; CAS no: 1219458-14-6 |
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(N-(3-aminopropyl)-N'-C16 - 18 (evennumbered), C18 unsaturated alkyl -propane 1,3-diamine | ||||
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| BCFBAF | Fraction of BCF |
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| Content | v3.01 | to weighted mean |
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Amine composition | (%) | Non-protonated fraction | BCF |
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C18:1 amine | 1 | 1930 | 19.3 |
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C16:0 propylenediamine | 5.7 | 521 | 29.7 |
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C18:1 propylenediamine | 8.4 | 1980 | 166.3 |
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C18:0 propylenediamine | 6.7 | 1550 | 103.9 |
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C14:0 dipropylenetriamine | 1.4 | 113 | 1.6 |
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C16:1 dipropylenetriamine | 1.3 | 363 | 4.7 |
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C16:0 dipropylenetriamine Y | 1.3 | 342 | 4.4 |
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C16:0 dipropylenetriamine | 21.3 | 503 | 107.1 |
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C18:1 dipropylenetriamine | 20.2 | 2030 | 410.1 |
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C18:0 dipropylenetriamine Y | 1.9 | 2120 | 40.3 |
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C18:0 dipropylenetriamine | 24.3 | 1590 | 386.4 |
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C16:0 tripropylenetetraamine | 1.9 | 486 | 9.2 |
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C18:1 tripropylenetetraamine | 1.8 | 2080 | 37.4 |
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C18:0 tripropylenetetraamine | 2.3 | 1630 | 37.5 |
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| Sum of fractions | Weighted mean BCF | ||
| 99.5 |
| 1357.9 | L/kg |
Van Beelen, P. (1998). Environmental risk evaluation of difficult substances in USES 2.0. RIVM rapport 679102045.
PERDU-DURAND, E, Nicole GASC, JeanPierre CRAVEDI (2006) Hexadecylamine biotransformation rates in carp and rainbow trout liver subcellular fractions. ERASM Final Report, Toulouse, France, July 2006. 1-14.
Bernhard, M. J., Dyer, S. D., Cowan-Ellsberry, C., & Center, M. V. I. (2006). Determination of In Vitro Biotransformation of C16 Primary Amine in Fish Hepatocyte Suspension. Environmental Risk Assessment and Management (ERASM), final report.
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