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Diss Factsheets
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EC number: 201-854-9 | CAS number: 88-73-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: migrated IUCLID4 data set
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The Toxicologist 11(1), 290 (1991)|(abstr.)
- Author:
- Mongan, A. et al.
- Year:
- 1 991
- Reference Type:
- publication
- Title:
- Drug Metabolism and Disposition 20, 436-439
- Author:
- Nomeir, A.A. et al.
- Year:
- 1 992
Materials and methods
Test material
- Reference substance name:
- 1-chloro-2-nitrobenzene
- EC Number:
- 201-854-9
- EC Name:
- 1-chloro-2-nitrobenzene
- Cas Number:
- 88-73-3
- Molecular formula:
- C6H4ClNO2
- IUPAC Name:
- 1-chloro-2-nitrobenzene
Constituent 1
Test animals
- Species:
- rat
Results and discussion
Any other information on results incl. tables
After a single non-occlusive, protective dermal application of 14 C-o-chloronitrobenzene at doses of
ca. 0.65, 6.5 or 65 mg/kg bw to male rats,
33-40 % of the doses of o-chloronitrobenzene was absorbed from the skin within 72 h;
the absorbed 14 C was excreted in urine (21-28 %) and faeces (11-15 %).
The extent absorption increased with an increase in dose from 0.65 to 6.5 mg/kg bw but increased only neglibly when the
dose was increased to 65 mg/kg bw.
The extent of urinary excretion of radioactivity was not significantly affected by dose over the range studied.
The initial rate of urinary excretion was also unaffected by dose.
The initial rate of faecal exretion increased with dose over the 0.65 to 6.5 mg/kg range, but decreased notably at the high dose.
Applicant's summary and conclusion
- Conclusions:
- 33-40 % of the doses of o-chloronitrobenzene was absorbed from the rat skin within 72 h;
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