Registration Dossier
Registration Dossier
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EC number: 203-462-3 | CAS number: 107-10-8
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Accumulation in organisms is not to be expected.
Key value for chemical safety assessment
Additional information
In accordance with Column 2 guidance of REACh Annex IX, testing is not required for substances having low bioaccumulation potential (e. g., log Kow < 3.0). The measured log Kow of this substance is 0.28, providing no bioaccumulative risk.
The bioaccumulation assessment is based on a key study (OASIS Catalogic v.5.11.9.8 baseline model v.02.05) and two supporting studies (US EPA T.E.S.T. v.4.1 and VEGA Meylan v.1.0.2). The key study considered mitigating factors like water solubility, metabolism and molecular size of the substance. It determined the BCF at 3.0 L/kg. The supporting studies, also estimation models, calculated the BCF at 1.8 (Meylan) and 3.0 (T.E.S.T.), respectively. Since the BCF values hardly differ from each other and the substance is in the applicability domain of the models, the calculations are supposed to be reliable.
Based on this approach with three different BCF values (range: 1.8 - 3.0), accumulation in organisms is not to be expected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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