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EC number: 222-746-8 | CAS number: 3598-16-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- other: Validation of the analytical method.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Version / remarks:
- 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.1075 (Freshwater and Saltwater Fish Acute Toxicity Test)
- Version / remarks:
- 1996
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Batch No.: 31233510
- Analytical monitoring:
- yes
- Details on sampling:
- For determination of the test item concentrations, five replicate samples were taken from the test solution (100 mg/L) and three replicate samples were taken from the control group at the start and at the end of the test.
- Vehicle:
- yes
- Details on test solutions:
- The test solution used in the test was prepared by mechanical dispersion. An amount of 0.5 g test item was dissolved in 5000 mL dilution water (ISO medium) in order to obtain the nominal concentration of 100 mg/L. The test solution was freshly prepared in the testing laboratory just before introduction of the test animals (start of the experiment).
Reconstituted water (ISO medium) was prepared according to Annex 2 of the OECD guideline 203. - Test organisms (species):
- other: Brachydanio rerio
- Details on test organisms:
- Species: Zebrafish (Brachydanio rerio)
Origin: Akvárium magazin Kft. (Pasaréti Gyula) 1222 Budapest, Dévény u. 36.
Number of animals: There were 10 animals at the treated and control group respectively (no parallels were used).
Age and size of animals: Juveniles; size within a range of 2.0 ± 1 cm. The loading of the test aquaria did not exceed 1.0 g / L.
Sex: Both female and male (were not separated).
Animal health: Apparently healthy animals were used in the test.
Acclimatization, holding of fish prior to the study: Fish were held for at least 12 days before test initiation in the fish laboratory of TOXI-COOP ZRT. under the same conditions as used during the exposure period.
During holding, fish were fed with appropriate, commercial diet for fish at least three times per week until one day before the test start. The health of the breeding was continuously monitored and any mortality or abnormal behaviour recorded. No mortality occurred in seven days before the start of the experiment, therefore the batch was considered to be acceptable for testing.
Light: 12 to 16 hours photoperiod daily.
Temperature: 21 – 25°C, constant within ± 1°C. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- No.
- Hardness:
- Hardness: approximate theoretical total hardness of 249 mg/L (as CaCO3).
- Test temperature:
- 21.9 - 22.1 °C
- pH:
- The measured pH values were in the range of 7.11 – 7.97 during the test.
- Dissolved oxygen:
- 74.3 - 85.7 %
- Salinity:
- /
- Conductivity:
- /
- Nominal and measured concentrations:
- Nominal: 0 and 100 mg/L.
Actual: 0 for the control. The average measured concentration of Sodium Phenoxyacetate was 99.2 mg/L at the start and 99.0 mg/L at the end of the test. - Details on test conditions:
- TEST MEDIUM / WATER PARAMETERS
Reconstituted water (ISO medium), prepared according to Annex 2 of the OECD guideline 203, was used.
OTHER TEST CONDITIONS
The test was carried out without adjustment of pH.
The light-dark cycle during the test was 16 hours light (artificial illumination) and 8 hours darkness.
The loading of the test aquaria did not exceed 1.0 g / L - Reference substance (positive control):
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: sub-lethal effects
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: sub-lethal effects
- Details on results:
- There were no mortality and any sub-lethal effect observed in 10 fish in the control group or in 10 fish exposed to a test concentration of 100 mg/L.
- Results with reference substance (positive control):
- /
- Reported statistics and error estimates:
- Not relevant.
- Validity criteria fulfilled:
- yes
- Conclusions:
- In this 96-hour static acute toxicity test on Zebrafish (Brachydanio rerio) the test item Sodium Phenoxyacetate had no toxic effect on fish up to a concentration of 100 mg/L. Accordingly, the 96-h LC50 value was determined to be >100 mg/L. The 96-h NOEC was determined to be 100 mg/L.
- Executive summary:
A 96-hour static acute toxicity test on Zebrafish (Brachydanio rerio) was performed according to the OECD guideline 203. The test item Sodium Phenoxyacetate had no toxic effect on fish up to a concentration of 100 mg/L. Accordingly, the 96-h LC50 value was determined to be >100 mg/L. The 96-h NOEC was determined to be 100 mg/L.
Reference
Description of key information
The LC50 of the test substance to Zebrafish is >100 mg/L.
The LC50 is not 100 mg/L, as one is forced to enter in the field below,
but the LC50 > 100 mg/kg.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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