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EC number: 249-934-2 | CAS number: 29895-73-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: OECD TG 401: LD50: 1993 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1972
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- Test was done before GLP came into force.
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Body Weight: 200-250 grams
- Fasting period before study: minimum 16 hours
- Diet: ad libitum
- Water: ad libitum - Route of administration:
- oral: unspecified
- Vehicle:
- water
- Doses:
- 1.31, 1.63, 2.05, 2.56 ml/kg
- No. of animals per sex per dose:
- 10 per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: The animals were observed 1 and 6 hours after application and thereafter daily
- Necropsy of survivors performed: yes - Preliminary study:
- A preliminare acute oral toxicity study is available in which 10 male rats were dosed orally with test substance at 5000 mg/kg, all 10 rats died during the study and therefore a second study was needed.
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 993 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 819 - <= 2 167
- Mortality:
- Dose: Mortality based on ml/kg can be converted to mg/kg bw multiplying it with 1.1586. The LD50 is 1720 ml/kg bw and in mg/kg bw 1993 mg/kg bw.
1.31 ml/kg bw: 2/10 deaths,
1.63 ml/kg bw: 4/10 deaths,
2.05 ml/kg bw: 7/10 deaths,
2.56 ml/kg bw: 9/10 deaths - Clinical signs:
- Ataxia, loss of righting reflex, shallow respiration and piloerection.
- Gross pathology:
- No abnormaities were noted in any of the animals at necropsy.
- Interpretation of results:
- other: Category 4
- Remarks:
- according to EU CLP 1272/2008 and its amendments
- Conclusions:
- The acute oral toxicity test showed an LD50 of 1993 mg/kg bw. In accordance with GHS criteria the substance needs to be classified as Category 4.
- Executive summary:
Acute oral toxicity: In this study, performed similar to OECD TG 401, 40 male rats (10/dose) were administered the substance at dose levels of 1.31, 1.63, 2.05, 2.56 ml/kg bw (1518 - 2966 mg/kg bw, using a density of 1.1586). At 1.31 ml/kg bw 2 of 10 animals died, at 1.63 ml/kg bw 4 of 10, at 2.05 ml/kg 7 of 10 and at 2.56 ml/kg 9 of 10 animals died. The rats showed ataxia, loss of righting reflex, shallow respiration and piloerection. No abnormalities were noted in any of the animals at necropsy. The calculated acute oral LD50 for the substance in male rats was 1993 mg/kg bw with 95% CL of 1819 -2167 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 993 mg/kg bw
- Quality of whole database:
- The acute oral toxicity result is of sufficient quality and adequate for this dossier.
Additional information
Acute oral toxicity: In this study, performed similar to OECD TG 401, 40 male rats (10/dose) were administered the substance at dose levels of 1.31, 1.63, 2.05, 2.56 ml/kg bw (1518 - 2966 mg/kg bw, using a density of 1.1586). At 1.31 ml/kg bw 2 of 10 animals died, at 1.63 ml/kg bw 4 of 10, at 2.05 ml/kg 7 of 10 and at 2.56 ml/kg 9 of 10 animals died. The rats showed ataxia, loss of righting reflex, shallow respiration and piloerection. No abnormalities were noted in any of the animals at necropsy.The calculated acute oral LD50 for the substance in male rats was 1993 mg/kg bw with 95% CL of 1819 -2167 mg/kg bw.
Acute dermal toxicity: An acute dermal toxicity study is
available (Moreno, 1972) in which a 24-hour test substance application
resulted in an LD50 > 2000 mg/kg bw. This information results in absence
of classification and labelling of the acute dermal toxicity and is
therefore not summarised in a study record.
Justification for classification or non-classification
Based on the acute oral LD50 value of 1992 mg/kg bw in the acute oral toxicity study the substance has to be classified for acute oral toxicity. According to EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 and its amendments the substance needs to be classified as acute toxic by the oral route, Category 4, H302: Harmful if swallowed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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