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EC number: 806-879-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
There are no data available investigating the aquatic toxicity of Tetraesters of pentaerythritol with 2-ethylhexanoic acid, heptanoic acid and nonanoic acid (EC 806-879-4). In order to fulfil the standard information requirements, in accordance with Annex XI, 1.5, of Regulation (EC) No 1907/2006, read-across from structurally related substances was conducted.
In accordance with Article 13 (1) of Regulation (EC) No 1907/2006, "information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI are met.” In particular for aquatic toxicity, information shall be generated whenever possible by means other than vertebrate animal tests, which includes the use of information from structurally related substances (grouping or read-across).
Having regard to the general rules for grouping of substances and read-across approach laid down in Annex XI, Item 1.5, of Regulation (EC) No 1907/2006 whereby substances may be predicted as similar provided that their physicochemical, toxicological and ecotoxicological properties are likely to be similar or follow a regular pattern as a result of structural similarity. The source substances Carboxylic acids, C5-9, tetraesters with pentaerythritol (CAS 67762-53-2), Decanoic acid, mixed esters with heptanoic acid, octanoic acid, pentaerythritol and valeric acid (CAS 71010-76-9) and Hexanoic acid, 2-ethyl-, pentaerythritol tetraester (CAS 7299-99-2) are considered to be similar on the basis of the structural similar properties and/or activities. The available endpoint information on the source substances is used to predict the aquatic toxicity of the target substanceTetraesters of pentaerythritol with 2-ethylhexanoic acid, heptanoic acid and nonanoic acid (EC 806-879-4).
The target substance is characterized as a tetraester of pentaerythritol and different fatty acids (C7, C9 and 2-ethylhexanoic acid). Carboxylic acids, C5-9, tetraesters with pentaerythritol is characterized as a tetraester of C5/C9 with pentaerythritol. Decanoic acid, mixed esters with heptanoic acid, octanoic acid, pentaerythritol and valeric acid is a tetraester of C5/C7/C9/C10 with pentaerythritol whereas Hexanoic acid, 2-ethyl-, pentaerythritol tetraester covers the content of 2-ethylhexanoic acid present in the target substance (2-ethylhexanoic acid tetraester with pentaerythritol).All selected source substances are representative for the target substance as they are all constituents of the target substance. They only differ slightly in their specification. However, none of the selected source substances contains any functional group which might change the overall mode of action and toxicity. A detailed analogue approach justification is provided in the technical dossier (see IUCLID Section 13).
All available experimental data on the source substances performed
according to internationally accepted guidelines indicate no evidence of
acute and chronic toxicity to aquatic organisms. Data for all three
trophic levels are available. No toxicity was observed up to the limit
of water solubility in all available experimental studies. The water
solubility of the target substance was determined to be < 0.15 mg/L at
20 °C.
The
short-term toxicity to fish was determined in standard OECD or Japanese
guidelines from suitable read-across substances. No mortality was
observed after 96 h resulting in effect values > the limit test
concentration (i.e. above the water solubility limit). The same was
recorded for the toxicity to aquatic algae. No inhibition of growth of
aquatic algae was observed in an experimental study according to
Japanese standard guidelines up to the limit of water solubility. Due to
the low water solubility, long-term testing to aquatic invertebrates was
considered to be necessary to assess the aquatic toxicity. The available
studies performed with suitable source substances resulted in a
NOELR/NOEC (21 d) ≥ 100 mg/L (nominal) and ≥ 0.0132 mg/L (measured time
weighted average) indicating no effects on reproduction up to the limit
of water solubility. Long-term toxicity testing to fish was not
considered to be necessary since there was no evidence from the
available data that fish are more sensitive compared to aquatic
invertebrates. No toxicity to fish was observed in the available acute
tests. Thus, in order to avoid unnecessary vertebrate testing, no
long-term testing with fish was proposed.
The
degradation process in commercial sewage treatment plants is not
suspected to be inhibited by the target substance. One available study
performed with activated sludge from a sewage treatment plant did not
indicate a risk since respiration of activated sludge microorganisms was
not inhibited.
Based on the result from structurally related read-across substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) it can be concluded that Tetraesters of pentaerythritol with 2-ethylhexanoic acid, heptanoic acid and nonanoic acid (EC 806-879-4) exhibits no toxic effects on freshwater organisms up to the limit of the water solubility. As it can be seen in the data matrix of the analogue justification in IUCLID Section 13, all reliable data from the target and the source substances support the read-across by showing a consistent pattern of results.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.