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EC number: 200-562-9 | CAS number: 63-68-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
No skin irritation study is available for L-methionine.
The dermal irritation of D,L-methionine was investigated with rabbits in a GLP study according to OECD guideline 404 (2001 -0082 -DGT). There was no indication of a systemic effect of the treatment. The single application (4 hours, semi-occlusive patch) of 0.5 g D,L-methionine to the intact skin of each of three rabbits doesn’t show any substance related change at the examination time-points 60 minutes, 24, 48, and 72 hours after patch removel. Therefore, D,L-methionine can be regarded as not skin irritating.
Read-across of the D,L-methionine study to L-methionine can be applied due to structural and physico-chemical similarities according to Reach regulation (Annex XI, 1.5). Further, L-methionine is present in a considerable amount in racemic methionine (approximatly 50%). The remaining 50% (D-methionine) contain the same set of functional groups and is not believed to have specific cell damaging/irritating properties. Taking this into account it can be concluded that D,L-methionine has the same skin irritation properties as L-methionine.
Therefore, based on the results of the read-across substance D,L-methionine, L-methionine can be regarded/classified as not skin irritating.
This is supported by the so-called BfR rulebase. Due to the physicochemical exclusion rules for skin irritation L-methionine is judged to be not classified as R34, R35, or R38 (rule: CNS group with melting point > 120°C).
Eye irritation
No eye irritation study is available for L-methionine.
The eye irritation potential of D,L-methionine was investigated with rabbits in a GLP study according to OECD guideline 405 (2001 -0084 -DGT). There was no indication of a systemic effect of the treatment. A single application of 100 mg D,L-methionine per animal into the conjunctival sac of the eye of three rabbits caused conjunctival redness (grade 1) in all animals 1 hour after instillation. The cornea and iris were not affected by instillation of the test compound. Based on this result D,L-methionine can be regarded as not eye irritating.
Read-across of the D,L-methionine study to L-methionine can be applied due to structural and physico-chemical similarities according to Reach regulation (Annex XI, 1.5). Further, L-methionine is present in a considerable amount in racemic methionine (approximatly 50%). The remaining 50% (D-methionine) contain the same set of functional groups and is not believed to have specific cell damaging/irritating properties. Taking this into account it can be concluded that D,L-methionine has the same eye irritation properties as L-methionine.
Therefore, based on the results of the read-across substance D,L-methionine, L-methionine can be regarded/classified as not eye irritating.
This is supported by the so-called BfR rulebase. Due to the physicochemical exclusion rules for eye irritation L-methionine is judged to be not classified as R36 (rule: CNS group with melting point > 200°C).Justification for classification or non-classification
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