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EC number: 257-471-2 | CAS number: 51850-20-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant, guideline study, available as unpublished report, no restrictions, fully adequate for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Hexachloroplatinic acid
- EC Number:
- 241-010-7
- EC Name:
- Hexachloroplatinic acid
- Cas Number:
- 16941-12-1
- Molecular formula:
- Cl6Pt.2H
- IUPAC Name:
- Hexachloroplatinic acid
- Test material form:
- liquid
- Details on test material:
- - Colour/form: orange liquid
- Density: 2.069 g/mL
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Duplicate samples of the control and of test concentrations were collated at the beginning and at the end of the test. Samples were taken from the approximate centre of the aquaria without mixing of the test media. Prior to analysis, samples were stored in a refrigerator.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: Stock solution of the highest test concentration of nominal 1000 mg/L was prepared by dissolving 300 mg test item into 3000 mL test water by intense stirring for 10 min. Adequate volumes of test medium were then diluted with test water to prepare test media.
- Controls: test medium without test item
Test organisms
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Common name: Rainbow trout
- Source: Forellenzuchtbetrieb Tautenhahn, 98646 Trostadt, Germany
- Age at study initiation: juveniles
- Length at study initiation (length definition, mean, range and SD): mean body length 4.5 ± 0.21 cm (n = 10)
- Weight at study initiation (mean and range, SD): mean body weight 1.15 ± 0.18 g (n = 10)
ACCLIMATION
- Acclimation period: 12 days
- Acclimation conditions (same as test or not): same as test
- Type and amount of food during acclimation: commercial fish diet
- Health during acclimation (any mortality observed): 4 fish died (< 5 %)
FEEDING DURING TEST: none
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Post exposure observation period:
- None
Test conditions
- Hardness:
- 250 mg/L as CaCO3
- Test temperature:
- 14 °C
- pH:
- 7.8 - 8
- Dissolved oxygen:
- 10.2 - 12.6 mg/L
- Nominal and measured concentrations:
- Nominal concentrations: 100, 46, 21, 10, 4.6 mg test item/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 20-L glass aquaria filled with 16 L test medium
- Aeration: slightly aerated throughout the test
- No. of organisms per vessel: 7
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: deionised water
- Total Hardness: 250 mg/L as CaCO3
- Alkalinity: 0.8 mmol/L
- Ca/mg ratio: 4:1 (based on molarity)
- Conductivity: < 5 μS/cm
- Intervals of water quality measurement: daily measurements
OTHER TEST CONDITIONS
- Photoperiod: 16 h light and 8 hour dark
- Light intensity: 200 - 1200 lux
EFFECT PARAMETERS MEASURED: Fish were observed every 24 hours for symptoms of intoxication and mortality.
TEST CONCENTRATIONS
- Spacing factor for test concentrations: about 2.1
- Range finding study
- Test concentrations: Not reported
- Results used to determine the conditions for the definitive study: the concentrations of the test item in the test medium were found to be constant throughout the test - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 76.55 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95 % Confidence Intervals: 53.89 - 108.75 mg test item/L
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 25.78 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- element
- Remarks:
- Pt
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95 % Confidence Interval: 18.15 - 36.63 mg Pt/L
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 21 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 7.07 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- element
- Remarks:
- Pt
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 46 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 15.49 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- element
- Remarks:
- Pt
- Basis for effect:
- mortality (fish)
- Details on results:
- In the control and at the test concentration up to 21 mg test item/L all fish survived until the end of the test. After 96 hours of exposure, one and five fish died at 46 and at 100 mg test item/L, respectively. After 96 hours of exposure at 100 mg test item/L, strong ventilation was observed in the two remaining fish.
- Reported statistics and error estimates:
- The LC50 and 95% Confidence Intervals were calculated by Probit analysis interpolation. The NOEC and LOEC values were directly determined from the raw data.
Any other information on results incl. tables
- Sublethal observations / clinical signs:
Table 1. Mortality and symptoms of toxicity of the test item to Oncorhyncus mykiss at 0, 24, 48, 72 and 96 hours of exposure. The reported values in the table represent the number of dead fish/number of fish with intoxication symptoms (dead fish are added to the sum of fish with symptoms)
Nominal concentration (mg test item/L) 0 h 24 h 48 h 72 h 96 h Control 0/0 0/0 0/0 0/0 0/0 4.6 0/0 0/0 0/0 0/0 0/0 10 0/0 0/0 0/0 0/0 0/0 21 0/0 0/0 0/0 0/0 0/0 46 0/0 0/0 0/0 0/0 1/1 100 0/0 1/1 1/5 (SV) 1/5 (SV) 5/7 (SV) LC50 (mg test item/L) > 100 > 100 > 100 > 100 76.55 95 % confidence intervals - - - - 53.89 - 108.75 SV = Strong Ventilation
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- The validity criteria were fulfilled as no fish died in the control and oxygen saturation was always > 60%
- Conclusions:
- The 96-hour LC50 of hexachloroplatinic acid to Rainbow trout (Oncorhynchus mykiss) was determined to be 76.55 mg test item/L, corresponding to 25.78 mg Pt/L.
- Executive summary:
The acute toxicity of hexachloroplatinic acid to Oncorhyncus mykiss was assessed. The study is reliable without restrictions, being GLP-compliant and having followed the standard guidelines OECD guideline 203 and EU Method C.1.
A static test procedure was followed. Five test concentrations were used and these were analysed using Graphite furnace-AAS method. As measured concentrations were above 100 % of the nominal values throughout the study, with a mean of 107 % of nominal, results were based on nominal concentrations. No protocol deviations were recorded. All validity criteria were met. The 96-hour LC50 was determined to be 76.55 mg test item/L, corresponding to 25.78 mg Pt/L.
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