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EC number: 266-959-4 | CAS number: 67707-75-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- study performed before implementation of GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Ethyl 3,5,5-trimethylhexanoate
- EC Number:
- 266-959-4
- EC Name:
- Ethyl 3,5,5-trimethylhexanoate
- Cas Number:
- 67707-75-9
- Molecular formula:
- C11H22O2
- IUPAC Name:
- ethyl 3,5,5-trimethylhexanoate
- Details on test material:
- - Name of test material (as cited in study report): 3,5,5-Trimethyl-ethyl capronate
- Analytical purity: 100%
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CF-1
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann
- Age at study initiation: young adult
- Weight at study initiation: 22 g (mean)
- Fasting period before study: yes
- Housing: no data
- Diet (e.g. ad libitum): pelleted species specific diet, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: 5 d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): approx. 22
- Humidity (%): approx. 50
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 185 - 397 g/L
MAXIMUM DOSE VOLUME APPLIED: 20 cm³/kg for all dose levels - Doses:
- 3160, 3980, 5010, 5660, 6310, 7940 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 5 280 mg/kg bw
- Based on:
- act. ingr.
- 95% CL:
- >= 4 700 - <= 5 900
- Mortality:
- 3160 mg/kg bw: 0/10 animals died
3980 mg/kg bw: 2/10 animals died
5010 mg/kg bw: 3/10 animals died
5660 mg/kg bw: 6/10 animals died
6310 mg/kg bw: 8/10 animals died
7940 mg/kg bw: 10/10 animals died - Clinical signs:
- reduced general condition, increased breathing frequency, abnormal posture (face-down position), diarrhea
- Body weight:
- no data
- Gross pathology:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the results obtained after a single oral administration to male mice, the oral LD50 of 3,5,5-Trimethyl-ethyl capronate was determined to be 5280 mg/kg bw.
- Executive summary:
In an acute oral toxicity study similar to OECD guideline 401, groups of 10 fasted male CF-1 mice were given a single oral dose of 3,5,5-Trimethyl-ethyl capronateat doses of 3160, 3980, 5010, 5660, 6310, 7940 mg/kg bw and observed for 14 days. No necropsy was performed; data on body weight changes are not available.
The following mortality was observed: 0/10 at 3160 mg/kg bw, 2/10 at 3980 mg/kg bw, 3/10 at 5010 mg/kg bw, 6/10 at 5660 mg/kg bw, 8/10 at 6310 mg/kg bw and 10/10 at 7940 mg/kg bw. Deaths occurred between day 1 and 4.
The surviving animals showed reduced general condition, increased breathing frequency, abnormal posture (face-down position), diarrhea.
The oral LD50 was determined to be 5280 mg/kg bw (95% c.i. 4700 – 5900 mg/kg bw).
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