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EC number: 212-842-8 | CAS number: 873-55-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer-reviewed Journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Dermal Irritation Assessment of Three Benzene Sulfonate Compounds
- Author:
- Chin H. Tay,Barbara T. Pugh,Stephen R. Clough and Brian H. Magee
- Year:
- 2 004
- Bibliographic source:
- International Journal of Toxicology ,January 2004 vol. 23 no. 1 pp.11-16
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2500 (Acute Dermal Irritation)
- Principles of method if other than guideline:
- A Skin irritation study was performed on New Zealand White rabbits to assess the irritation potential of disodium Benzene meta-disulfonate
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Disodium benzene-1,3-disulphonate
- EC Number:
- 212-606-4
- EC Name:
- Disodium benzene-1,3-disulphonate
- Cas Number:
- 831-59-4
- Molecular formula:
- C6H6O6S2.2Na
- IUPAC Name:
- disodium benzene-1,3-disulfonate
- Test material form:
- solid: granular
- Details on test material:
- - Name of test material (as cited in study report): benzene meta-disulfonate
- Molecular formula : C6H6O6S2.2Na
- Molecular weight : 282.204 g/mol
- Smiles notation: S(=O)(=O)([O-])c1cc(S(=O)(=O)[O-])ccc1.[Na+].[Na+]
- InChl : 1S/C6H6O6S2.2Na/c7-13(8,9)5-2-1-3-6(4-5)14(10,11)12;;/h1-4H,(H,7,8,9)(H,10,11,12);;/q;2*+1/p-2
- Substance type: Organic
- Physical state: Solid
-Purity:Pure compound
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): disodium benzene meta-disulfonate
- Molecular formula : C6H6O6S2.2Na
- Molecular weight : 282.204 g/mol
- Smiles notation: S(=O)(=O)([O-])c1cc(S(=O)(=O)[O-])ccc1.[Na+].[Na+]
- Lot number: G6341A
- InChl : 1S/C6H6O6S2.2Na/c7-13(8,9)5-2-1-3-6(4-5)14(10,11)12;;/h1-4H,(H,7,8,9)(H,10,11,12);;/q;2*+1/p-2
- Substance type: Organic
- Physical state: Solid
-Purity:Pure compound
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Millbrook Rabbit Breeding Labs in Amherst, MA.
- Age at study initiation:10 weeks old
- Weight at study initiation: between 2.03 and 2.24 kg
- Fasting period before study:No data
- Housing: Rabbits were housed individually in suspended stainless steel cages with noncontact hardwood chips as bedding
- Diet (e.g. ad libitum): TEK 8630 Rabbit Diet;ad libitum
- Water (e.g. ad libitum): tap water, ad libitum.
- Acclimation period:No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 68 deg.F (±5 deg.F) (20deg.C)
- Humidity (%):between 30% and 70%
- Air changes (per hr): 10 to 15 air exchanges per hour
- Photoperiod (hrs dark / hrs light): 12-hour light/dark cycle of full spectrum fluorescent lights
IN-LIFE DATES: From: To:No data
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- other: Distillled water
- Controls:
- yes
- Amount / concentration applied:
- 5000 and 2000 mg/L
- Duration of treatment / exposure:
- 4-hrs.
- Observation period:
- 1, 24, 48, and 72 hours after patch removal
- Number of animals:
- Total: 12
5000 mg/L: 3 Male and 3 female
2000 mg/L: 3 Male and 3 female - Details on study design:
- TEST SITE
- Area of exposure: small area of skin(rabbits trunk)
- % coverage: approximately 6cm2
- Type of wrap if used: semiocclusive
REMOVAL OF TEST SUBSTANCE
- Washing (if done): the patches were
removed and the skin wiped to remove any test substance still remaining
- Time after start of exposure: At the end of the 4-hour exposure period
SCORING SYSTEM: Draize Scale for Scoring Skin Reactions (USEPA 1998)
This scale assesses irritation as follows: 0, no erythema or edema; 1, very slight erythema and/or edema (barely perceptible); 2, well-defined erythema and/or slight edema; 3, moderate to severe erythema or moderate edema, and 4, severe erythema and/or edema.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1,24,48,72 hrs
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: At dose concentration 2000 mg/l
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1,24,48,72 hrs
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: At dose concentration 2000 mg/l
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1 hr.
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: At dose concentration 5000 mg/l
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 hrs.
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: At dose concentration 5000 mg/l
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 48 hrs.
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: At dose concentration 5000 mg/l
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 72 hrs.
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: At dose concentration 5000 mg/l
- Irritant / corrosive response data:
- Control skin showed no signs of irritation.Irritation was completely reversible within 72 hours.
- Other effects:
- An increase in the body weight of the animals dosed 5000 and 2000 mg/L test material was observed. No signs of toxicity were noted.
Any other information on results incl. tables
Table 1: Clinical Observations
Compound |
Dosagea(mg/l) |
N |
Body weight (kg)b |
Weight changeb |
Signs of toxicityc |
|
Day 0 |
Day 3 |
|||||
Benzene meta-disulphonate |
5000 |
3 |
2.17±0.038 |
2.23±0.053 |
0.06±0.015 |
none |
Benzene meta-disulphonate |
2000 |
3 |
2.16±0.075 |
2.20±0.075 |
0.04±0.012 |
none |
a-
b-
c-
Table 2: Summary of irritation tests for benzene meta-disulphonate
Time (in hours)a |
Concentration appliedb(mg/l) |
Effects |
1 |
5000 |
Very slight or well defined erythema in all animals |
24 |
Very slight erythema in 2 of 3 animals |
|
48 |
Very slight erythema in 1 of 3 animals |
|
72 |
None observed |
|
Conclusion |
Slight irritant reversible in 72 hours |
|
1 |
2000 |
None observed |
24 |
None observed |
|
48 |
None observed |
|
72 |
|
None observed |
Conclusion |
Not an irritant |
a- Time refers to time elapsed following the 4-hour exposure to the test substance.
b- Dermal application volume was 0.5 ml.
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- At 5000 mg/L, very slight (one animal, Draize Score 1) and well defined erythema (two animals, Draize Score 2) were observed 1 hour after removal of the test substance. At the 24-hour observation point, only two animals demonstrated very slight irritation. By 48 hours, very slight irritation remained on only one of the two test animals. By 72 hours, no irritation was observed on any animal.
No erythema or edema was observed in any test animals at 2000 mg/L.
Since the effects at 5000mg/l were fully reversible within 72 hours and not observed at 2000 mg/l, disodium Benzene meta-disulfonate can be considered not irritating to rabbit skin. - Executive summary:
A Skin irritation study was performed on New Zealand White rabbits to assess the irritation potential of disodiumBenzenemeta-disulfonate. The study was performed according to EPAOPPTS 870.2500, “Acute Dermal Irritation” Guidelines.
Two concentrations of disodium benzene meta-disulfonate were tested in separate groups of animals, 3 female and 3 male rabbits: 5000 and 2000 mg/L. The pH of the 5000 mg/L test substance ranged from 7.07 to 6.22 prior to dosing and after the 4-hour exposure. The pH of the 2000 mg/L test substances, measured prior to dosing and after the 4-hour exposure, ranged from 7.04 to 6.96.
Each dose of test compound (0.5 ml of each concentration for each dose cohort) was applied to a small area of skin (approximately 6cm2) and covered with four layers of gauze patch held in place with nonirritating tape. Since the compound was in liquid form, it was applied to the gauze before application to the skin. The patch was loosely held in contact with the skin using a semi-occlusive dressing for the exposure period of 4 hours.
At the end of the 4-hour exposure period, the patches were removed and the skin wiped to remove any test substance still remaining. Animals were observed for signs of erythema and edema at 1, 24, 48, and 72 hours after patch removal. Observations of erythema or edema were scored according to the Draize Scale for Scoring Skin Reactions (USEPA 1998). This scale assesses irritation as follows: 0, no erythema or edema; 1, very slight erythema and/or edema (barely perceptible); 2, well-defined erythema and/or slight edema; 3, moderate to severe erythema or moderate edema, and 4, severe erythema and/or edema. Animals were weighed before exposure and at the end of the exposure period (day 3) and observed daily for the incidence of any clinical signs of toxicity (other than erythema and edema). Control skin showed no signs of irritation.
At 5000 mg/L, very slight (one animal, Draize Score 1) and well defined erythema (two animals, Draize Score 2) were observed 1 hour after removal of the test substance. At the 24-hour observation point, only two animals demonstrated very slight irritation. By 48 hours, very slight irritation remained on only one of the two test animals. By 72 hours, no irritation was observed on any animal. No erythema or edema was observed in any test animals at 2000 mg/L.
Since the effects at 5000mg/l were fully reversible within 72 hours and not observed at 2000 mg/l,disodium Benzenemeta-disulfonate can be considered not irritating to rabbit skin.
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