Registration Dossier
Registration Dossier
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EC number: 243-325-5 | CAS number: 19800-42-1
Endpoint summary
Administrative data
Description of key information
The adsorption coefficient log Koc of the test substance was determined to be 5.65 for soil and 5.93 for sewage sludge at pH 5.5 (21.1 °C) and 3.52 for soil and 3.51 for sewage sludge at pH 7.5 (20.8 °C). For risk assessment purposes (PNEC derivation), the soil log Koc of 5.65 (Koc: 446683.6) at pH 5.5 will be retained as this represents a worst case for the soil compartment.
Additional information
A study was conducted to determine the adsorption coefficient (Koc) of the test substance (94.8% purity) on soil and on sewage sludge using high performance liquid chromatography (HPLC) according to OECD Guideline 121 and EU Method C.19. Two pH values were used since the test substance is ionisable in the relevant pH range of 5.5 to 7.5. The temperature was controlled (21.1 °C for the buffer 5.5 and 20.8 °C for the buffer 7.5, mean value). A methanol : KH2PO4(pH 5.5) (70 : 30 v/v) and a methanol : KH2PO4 buffer (pH 7.5) (70 : 30 v/v) were used as mobile phases. A 10mg/L sample of the test substance was analysed threefold via HPLC on a cyanopropyl (CN-) column with DAD detection. Calibrations were performed using eight reference items for soil and seven reference items for sewage sludge with known log Koc values (given by the guidelines). The reference items were measured twice, once before and once after the measurement (double injection of one replicate) of the test item. Dead time of the HPLC-system was determined with sodium nitrate. Two individual log Koc values for soil and for sewage sludge were derived under consideration of the first and second calibration at each pH value. Finally, a mean value for soil and for sewage sludge was calculated from these individual log Koc values. The log Koc values were determined to be 5.65 for soil and 5.93 for sewage sludge at pH 5.5 (21.1 °C). Values at pH 7.5, extrapolated because the retention time of the test item was higher than that of the reference item with the highest log Koc, were equivalent to 3.52 for soil and 3.51 for sewage sludge (20.8 °C) (Landsberg, 2016).
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