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Diss Factsheets
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EC number: 235-845-6 | CAS number: 13005-36-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation -
The skin irritation potential was identified in a literature paper which is off accepted scientific standard (Motoyoshi K et al 1979), however was not sufficient for C& L. The paper looked at the skin irritancy potential of the read-across substance phenethyl alcohol in Guinea pigs, rabbits, miniature swine and humans.
Eye irritation:
The eye irritation potential was identified in a key study conducted to OECD Guideline 405 (Acute Eye Irritation / Corrosion) on the read-across substance phenylacetic acid.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin Irritation:
Test on Guinea pigs and rabbits on the read-acoss subtance Phenylethyl alcohol led to the conclusion that the substance is a moderate irritant, however the test on miniature swine did not show any irritant effects. This is not sufficient for C & L purposes as the total score was the average of the reddening rate ( erythema, 72 h reading), the dilating rate, the swelling rate, and the bluing rate of 6 animals in a group. Only two parameters out of these can be used for C & L purposes therefore the subtance cannot be classified as a moderate irritant.
A patch test on a panel of 50 male adults on the read-acoss subtance Phenylethyl alcohol (in 32% actone) was found to be negative for skin irritation. Since no skin irritation effect were seen in miniature swine and in particular the humans patch test the substance Phenylethyl alcohol was concluded as not an skin irritant overall.
Effects on eye irritation: highly irritating
Justification for classification or non-classification
Eye Irritation:
The eye irritation study conducted to OECD Guideline 405 (Acute Eye Irritation / Corrosion) on the read-across substance phenylacetic acid has been concluded as a GHS category 1 eye irritation. It was found that in at least 2 animal's effects on the cornea were not fully reversed fully within an observation period of 21 days, thus leading to the justification of the GHS categoty 1 classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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