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EC number: 272-683-5 | CAS number: 68908-82-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- Method provided in 'Details on Oral Exposure'
LD50 was calculated according to the method of Litchfield, J.T. Jr., & F. Wilcoxon JPET 96:99, 1949. - GLP compliance:
- no
- Remarks:
- study pre-dates introduction of GLP
- Limit test:
- yes
Test material
- Reference substance name:
- η-1H-indol-3-yl-α,α,ε-trimethyl-1H-indole-3-heptanol
- EC Number:
- 267-434-2
- EC Name:
- η-1H-indol-3-yl-α,α,ε-trimethyl-1H-indole-3-heptanol
- Cas Number:
- 67860-00-8
- Molecular formula:
- C26H32N2O
- IUPAC Name:
- 8,8-di(1H-indol-3-yl)-2,6-dimethyloctan-2-ol
- Reference substance name:
- Indole
- EC Number:
- 204-420-7
- EC Name:
- Indole
- Cas Number:
- 120-72-9
- Molecular formula:
- C8H7N
- IUPAC Name:
- 1H-indole
- Reference substance name:
- 7-hydroxycitronellal
- EC Number:
- 203-518-7
- EC Name:
- 7-hydroxycitronellal
- Cas Number:
- 107-75-5
- Molecular formula:
- C10H20O2
- IUPAC Name:
- 7-hydroxy-3,7-dimethyloctanal
- Reference substance name:
- 1-(1H-indol-1-yl)-3,7-dimethyloctane-1,7-diol
- Cas Number:
- 1642782-49-7
- Molecular formula:
- C18H27NO2
- IUPAC Name:
- 1-(1H-indol-1-yl)-3,7-dimethyloctane-1,7-diol
- Reference substance name:
- Unknown constituents
- IUPAC Name:
- Unknown constituents
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Constituent 5
- Specific details on test material used for the study:
- Sample Label: 79-44, Indolene, Lot # 14
Sample received: 12/27/79
Test animals
- Species:
- mouse
- Strain:
- Swiss Webster
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Swiss Webster mice, approximately 8 weeks old, when received were equilibrated for at least one week in the laboratory. Apparently healthy mice were selected for the test.
The animals were identified by cage tags noting the test material, starting date, animal number and sex.
The animals were housed 5 / cage in suspended wire mesh cages (20'' x 10'' x 7''). Fresh Purina mouse chow and water were freely available except for 16-20 hours prior to dosing when the food was removed. The animal room, reserved exclusively for rodents on acute tests, was maintained at 20 - 21 °C and was kept clean in accordance with the standards of AAALAC of which the laboratory is an approved member.
Supplied: Ace Animals
Weight range: 14 - 16 g
Sex: 10 males
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- The test material was given orally by syringe and 18 gauge blunt end needle. One group of 10 male mice was dosed at 5.0 g/kg of body weight. For liquid materials, the dose was based on the sample weight as calculated from the specific gravity. The vehicle, if any, was chosen becuase of its lack of known toxicity, lack of physiological effect and because it is relatively unreactive with other chemical substances.
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 10 males
- Control animals:
- no
- Details on study design:
- Observations: The mice were observed 3-4 hours after dosing and once daily for 14 days. Mortality, toxicity and pharmacological effects were recorded.
Termination: At 14 days the survivors were sacrificed. All animals were examined for gross pathology.
The LD50 was calculated according to the method of Litchfield, J.T. Jr., & F. Wilcoxon JPET 96:99, 1949.
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 4/10. Four animals died at this dose level. Two animals died 3-4 hours post dose, one animal on Day 1 and one animal Day 2.
- Clinical signs:
- other: Five or more animals showed signs of lethargy, ptosis and piloerection 3-4 hours post dose. Signs of tremors, ptosis and lethargy were noted during the study. Three animals were normal on Day 14.
- Gross pathology:
- Six animals, sacrificed of Day 14, were normal and showed no gross pathologies. Animals which died showed signs of brown stain at nose /mouth area; slightly or moderatley congested lungs; slightly hemorrhagic lungs; slightly dilated heart; stomachs slightly red; intestines slightly red; and intestines moderatley distended by mucus.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test material is not toxic, as defined in 16 CFR 1500.3, at a dose level of 5.0 g/kg of body weight.
- Executive summary:
Four out of ten male mice died at a dose of 5000 mg/kg Indolene. The most common signs of toxicity were lethargy, ptosis and piloerection. Internal organs of all surviving animals showed no gross pathology. Animals that died prior to Day 14 had respiratory, cardiac and gastrointestinal abnormalities.
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