Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 266-722-5 | CAS number: 67583-77-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 August - 23 September 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given, but considered sufficiently reliable for the purpose of hazard assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Maximization procedure was performed on 30 healthy male and female volunteers (26 completed the study) to determine the sensitizing potential of test item.
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-ethoxy-1,1,5-trimethylcyclohexane
- EC Number:
- 266-722-5
- EC Name:
- 3-ethoxy-1,1,5-trimethylcyclohexane
- Cas Number:
- 67583-77-1
- Molecular formula:
- C11H22O
- IUPAC Name:
- 3-ethoxy-1,1,5-trimethylcyclohexane
- Test material form:
- not specified
Constituent 1
Method
- Type of population:
- general
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed:
- Sex: 30 males and females
- 26 subjects completed the study - Clinical history:
- None
- Controls:
- SLS controls were placed on the left and petrolatum on the right and labeled site 5.
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: patch test (epicutaneous test)
ADMINISTRATION
- Type of application: occlusive
METHOD
- Pre test: A patch of each test material was applied to normal sites on the backs for 48 h under occlusion. No significant evidence of irritation was observed, and all subjects were pretested with 7.5 % sodium lauryl sulfate (SLS).
- Maximization procedure: Modified after JID 47:393-409, 1966
The materials were applied under occlusion to the same sites on the volar aspects of the forearms of all subjects for 5 alternate day 48 h periods. Patch sites were pretreated for 24 h with 7.5 % aqueous SLS under occlusion for the initial patch only. Following a 10-14 day rest period, challenge patches of all materials were applied under occlusion to fresh sites for 48 h. Challenge applications were preceded by 30 minute applications of 7.5 % aqueous SLS under occlusion without SLS treatment on the right side. Additional SLS controls were placed on the left and petrolatum on the right and labeled site 5.
Results and discussion
- Results of examinations:
- After 48 and 72 h challenge exposure, SLS produced slight burns on the challenge in approximately half of the subjects as expected. No other significant allergic or irritant reactions were observed.
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Conclusions:
- Under the test conditions, test item produced no reactions that were considered significantly irritant or allergic in the 26 subjects tested.
- Executive summary:
In the sensitisation study, 30 healthy male and female volunteers were screened and 26 completed the study (Maximization procedure). The test item was applied on the volar aspects of the forearms of all subjects under occlusion for 5 alternate day 48 h periods. Patch sites were pretreated for 24 h with 7.5 % aqueous SLS under occlusion for the initial patch only. Following a 10-14 day rest period, challenge patches of all materials were applied under occlusion to fresh sites for 48 h. Challenge applications were preceded by 30 minute applications of 7.5 % aqueous SLS under occlusion without SLS treatment on the right side. Additional SLS controls were placed on the left and petrolatum on the right and labeled site 5.
SLS produced slight burns on the challenge in approximately half of the subjects as expected. No other significant allergic or irritant reactions were observed.
Under the test conditions, test item produced no reactions that were considered significantly irritant or allergic in the 26 subjects tested.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.