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EC number: 237-706-5 | CAS number: 13933-32-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 3 days; no data on dates (Report date January 1977)
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Not according to modern guidelines. No control sites; test material not washed off after the 24 hr exposure period.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: US Federal register Vol. 38, No. 187, section 1500:41 (1973)
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- Tetraammineplatinum dichloride
- EC Number:
- 237-706-5
- EC Name:
- Tetraammineplatinum dichloride
- Cas Number:
- 13933-32-9
- Molecular formula:
- Cl.1/2H12N4Pt
- IUPAC Name:
- Tetraammineplatinum dichloride
- Details on test material:
-Name of test material (as cited in study report): tetrammineplatinous chloride
- Substance type: no data
- Physical state: solid
- Analytical purity: no data
- Impurities (identity and concentrations): no data
- Composition of test material, percentage of components: no data
- Purity test date:no data
- Lot/batch No.: no data
- Expiration date of the lot/batch: no data
- Stability under test conditions: no data
- Storage condition of test material: no data
- Other:
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: “recognised breeders”
- Age at study initiation: 12-14 weeks
- Weight at study initiation: about 2.2 kg
- Housing: Individually housed; type of cage not specified
- Diet (e.g. ad libitum): conventional diet, ad libitum
- Water (e.g. ad libitum): filtered water, ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 15-19
- Humidity (%): 50-70
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): natural lighting
IN-LIFE DATES: From: To:
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: shaved & abraded
- Vehicle:
- not specified
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 500 mg (no data if applied as the powder or made into a paste - Duration of treatment / exposure:
- 24 hr
- Observation period:
- 24 and 72 hr
- Number of animals:
- Six females
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm each of shaved dorsal skin and shaved and abraded dorsal skin
- % coverage: no data
- Type of wrap if used: applied on gauze held in place with “Sleek” adhesive tape. Entire trunk covered with an elastic bandage
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data; presumably substance not removed
- Time after start of exposure:
SCORING SYSTEM: assessed for primary irritation index at 24 and 72 hr. Scores for erythema/eschar formation and edema for both intact and abraded skin at both time points were totalled and divided by 24 to give the primary irritation index.
Primary irritation index Classification
0 non-irritant
> 0-2 mild irritant
> 2-5 moderate irritant
> 5-8 severe irritant
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: Mean of 24- and 72-hr time points
- Score:
- 2.8
- Max. score:
- 8
- Reversibility:
- other: not assessed; animals only kept for 48 hrs after removal of the patch.
- Remarks on result:
- other: Score is the mean for intact and abraded skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: Mean of 24- and 72-hr time points
- Score:
- 5
- Max. score:
- 16
- Reversibility:
- other: not assessed; animals only kept for 48 hrs after removal of the patch.
- Remarks on result:
- other: Score is the mean for intact and abraded skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: Mean of 24- and 72-hr time points
- Score:
- 6.2
- Max. score:
- 16
- Reversibility:
- other: not assessed; animals only kept for 48 hrs after removal of the patch.
- Remarks on result:
- other: Score is the mean for intact and abraded skin
- Other effects:
- No indication that systemic effects were assessed.
Any other information on results incl. tables
Table 1: Individual rabbit results
Rabbit No. | Time/hr | Erythema | Oedema | ||
Abraded skin | Intact skin | Abraded skin | Intact skin | ||
1 | 24 | 1 | 1 | 2 | 2 |
72 | 1 | 1 | 1 | 1 | |
2 | 24 | 1 | 1 | 1 | 1 |
72 | 1 | 1 | 1 | 1 | |
3 | 24 | 2 | 2 | 2 | 2 |
72 | 2 | 2 | 2 | 2 | |
4 | 24 | 1 | 1 | 2 | 2 |
72 | 1 | 1 | 1 | 1 | |
5 | 24 | 1 | 1 | 3 | 1 |
72 | 1 | 1 | 1 | 0 | |
6 | 24 | 1 | 1 | 2 | 2 |
72 | 2 | 2 | 2 | 2 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- In a US guideline study, moderate irritation was observed following a single 24-hr semi-occluded application of tetraammine platinous chloride to the intact or abraded skin of three rabbits.
- Executive summary:
In a US guideline study, the irritant potential of tetraammine platinous chloride was assessed on the intact and abraded skin of six female New Zealand white rabbits.
The test substance (0.5 g) was applied for 24-hr under semi-occlusion and assessed immediately upon removal of the patch as well as 48 hr later. Residual test material was not washed off the skin during this period. Moderate irritation was observed at both time points. Similar scores for both erythema/eschar formation and edema were reported for intact and abraded skin. The primary irritation index was calculated to be 2.8.
Mean erythema/eschar and oedema scores were below 2.3 for all six animals. However, the effects were only observed to be reversible in one animal within the 48-hr observation period.
Based on the results of this study, tetraammine platinous chloride should be classified as a skin irritant (category 2) according to EU CLP criteria (EC 1272/2008).
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