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Diss Factsheets
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EC number: 201-166-9 | CAS number: 79-00-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key values were obtained from a chronic oral NCI study with mice (1978) and the sub-chronic inhalation study with rats (UNEP 2000).
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 300 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- mouse
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEC
- 83 mg/m³
- Study duration:
- chronic
- Species:
- rat
Additional information
A 14-day study by gavage in CD-1 mice was performed for selecting doses to be used in a 90-day drinking water study in the same mouse species. Doses selected were 20, 200 and 2000 mg/L for the 90-day drinking water study. In the 90-day drinking water study, effects were observed in mouse liver (White et al., 1985). The NOAEL in females was 3.9 mg/kg/day (20 mg/L), based on the reduction of cytochrome P-450 levels and aniline hydroxylase activity. In males, the NOAEL was 4.4 mg/kg/day (20 mg/L), based on reduction of liver glutathione. Histopathological examination was not conducted in this study, limiting the interpretation of the study results. As part of carcinogenicity studies on mouse and rat, chronic effects on bodyweight gain, mortality and clinical signs were examined following administration of substance by gavage (NCI, 1978). NOAEL was derived at 300 mg/kg bw/d in mouse. No NOAEL was derived in the rat study as clinical signs, such as hunched appearance, rough fur, urine stains on the abdominal area, dyspnea and squinted eyes, were observed at the lowest dose tested, i.e. 35 mg/kg bw/d. The latter study was not retained for the key value because only aspecific changes were observed.
Only summaries (UNEP review document, 2000) were available for repeated inhalation exposure studies.
Repeated inhalation exposure (7 hours/day, 5 days/week) to 83 mg of 1,1,2-trichloroethane/m3 air for 6 months did not lead to substance-related histopathological, hematological and biochemical changes in the rat, guinea pig and rabbit. Body weight gain, organ weights and mortality remained unaffected. Therefore, NAOEL was considered to be 83 mg/m3, equivalent to roughly 11.1 mg/kg/day in the rat, 7.43 mg/kg/day in the guinea pig, and 24.9 mg/kg/day in the rabbit.
No relevant dermal exposure toxicology studies were available in literature.
Repeated dose toxicity: via oral route - systemic effects (target organ) digestive: liver
Justification for classification or non-classification
Considering organ-specific toxicity, no studies were identified which convincingly confirmed a need for classification.
No classification was also deemed necessary by European authorities regarding repeated oral or inhalation exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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