Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 209-987-4 | CAS number: 600-22-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Acutely not toxic to aquatic organisms.
Methyl pyruvate is very unstable in contact with water and hydrolysis rapidly into pyruvate and methanol. A large amount of data on the toxicity of methanol is available for a broad spectrum of aquatic organisms (fish, invertebrates and algae). The results from the most reliable and relevant available studies are listed below.
The second hydrolysis product is pyruvate for which no data on aquatic toxicity are available. However, pyruvate can be encymatically reduced by lactate dehydrogenase to produce lactic acid. Both molecules are structural closely related and of central improtance for the celluar metabolism. There is an ECHA dessiminated dossier available which proves lactic acid to be acutely not toxic to auqatic organisms.
Short-term toxicity of methanol:
Fish
LC50 (96h) = 28100 mg/L Pimephales promelas
LC50 (96h) = 20100 mg/L Oncorhynchus mykiss
LC50 (96h) = 15400 mg/L Lepomis macrochirus
Daphnids
EC50 (48h) = 18000 mg/L Daphnia magna
EC50 (48h) > 10000 mg/L Daphnia magna
Green algae
EC50 (96h) ca. 22000 mg/L Selenastrum capricornutum
Short-term toxicity of lacic acid (ECHA dessiminated data):
Fish
LC50 (96h) = 130 mg/L Oncorhynchus mykiss
LC50 (96h) = 195 mg/L Danio rerio
LC50 (96h) = 130 mg/L Lepomis macrochirus
Daphnids
EC50 (48h) = 750 mg/L Daphnia magna
EC50 (48h) = 130 mg/L Daphnia magna
Green algae
EC50 (96h) > 2800 mg/L Pseudokirchneriella subcapitata
All the available data demonstrate consistently the very low acute toxicity to methanol and pyruvate (via read-across to lactic acid) for aquatic organisms.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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