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Diss Factsheets
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EC number: 204-255-0 | CAS number: 118-48-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- fertility, other
- Remarks:
- based on test type (migrated information)
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- no data
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Significant methodological deficiencies, poorly documented.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Antifertility Effects of Isatoic Anhydride and Derivatives.
- Author:
- Cutting WC et al.
- Year:
- 1 966
- Bibliographic source:
- Med Pharmacol Exp 15: 7-16.
- Reference Type:
- review article or handbook
- Title:
- Toxikologische Bewertung No. 224: N-Carboxyanthranilsäureanhydrid. Issue 02/92
- Author:
- Anonymous
- Year:
- 1 992
- Bibliographic source:
- Berufsgenossenschaft der Chemischen Industrie, Heidelberg, ISSN 0937-4248.
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- no
- Remarks:
- pre-GLP study
- Limit test:
- no
Test material
- Reference substance name:
- 4H-3,1-benzoxazine-2,4(1H)-dione
- EC Number:
- 204-255-0
- EC Name:
- 4H-3,1-benzoxazine-2,4(1H)-dione
- Cas Number:
- 118-48-9
- Molecular formula:
- C8H5NO3
- IUPAC Name:
- 4H-3,1-benzoxazine-2,4(1H)-dione
- Details on test material:
- Isatoic anhydride; no further data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no further data
Administration / exposure
- Route of administration:
- other: oral:feed; changed to injection (not further specified) during the course of the study
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- no data
- Duration of treatment / exposure:
- 21 or 5 days; see below
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
ca. 2000, 4000 mg/kg bw/d (1, 2% in the diet)
Basis:
nominal in diet
- Control animals:
- yes, plain diet
Results and discussion
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
Isatoic anhydride was tried for antifertility effects in the usual 5-day plan in which the female only was treated. The results are shown in the table below. The right hand column shows the degree of inhibition as compared to controls. Isatoic anhydride appeared to show the most consistent action with a usual decrease in litters of at least 50%. The values given for administration by diet involve treatment of both males and females; those for injection females only. The weight changes indicate a generally slightly greater weight loss during the period of mating in females receiving treatment compared to untreated controls.
Applicant's summary and conclusion
- Executive summary:
Abstract
A number of derivatives of isatoic anhydride, in particular benzoketotriazine, somewhat reduced the number of subsequent litters in female white Swiss mice. When administration was delayed until after mating the effect appeared to be increased, suggesting an effect during tubal transit or implantation. Treatment of males instead of females at intervals up to a month before mating also appeared to reduce subsequent litters slightly. Benzoketotriazine did not upset normal cycling in female mice, nor produce testicular damage detectable histologically 3,5 weeks after administration.
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