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Diss Factsheets
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EC number: 700-126-2 | CAS number: 12185-56-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: other: various in vitro systems
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- publication
- Title:
- Cadmium Metal and Cadmium Oxide - Summary Risk Assessment Report
- Author:
- Institute for Health and Consumer Protection, European Chemicals Bureau
- Year:
- 2 008
- Bibliographic source:
- European Union Risk Assessment Report, Cadmium Oxide and Cadmium Metal. Part II Human Health (publication EUR 22766 EN), Volume 75. 4.1.2.8.2 pp 369-373.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.5265 (The Salmonella typhimurium Bacterial Reverse Mutation Test)
- Deviations:
- no
- GLP compliance:
- not specified
- Type of assay:
- bacterial gene mutation assay
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Type:
- Constituent
- Type:
- Constituent
Results and discussion
- Additional information on results:
- Cadmium oxide (particle size not given) at doses of 1466 μg/ml or 147 μg/ml did
not induce reverse mutations (Mortelmans, 1986 cited in IARC 1993). No genotoxic effects
were noted when CdO was tested at doses of 3.3 to 3333 μg CdO/plate in four strains of
Salmonella, using a preincubation protocol with and without liver S9 metabolic activation
enzymes (from Aroclor-induced male SD rats and Syrian hamsters) (Zeiger et al., 1992 cited
in NTP Technical Report, 1995).
Any other information on results incl. tables
There is some evidence that treatment of bacteria with Cd ions results in strand breaks (or at least DNA of smaller weight). This was first seen in E.Coli by Mitra et al. (1975). Authors reported moreover a cadmium tolerance mechanism in this strain: growing E.Coli in 3 μM Cd2+ led to an initial decrease in colony-forming ability followed by a gradual accommodation of the cells. During the initial phase, cellular DNA was found to contain single strand breaks which were later repaired (Mitra et al., 1975 cited in IARC 1992).
Applicant's summary and conclusion
- Conclusions:
- No in vitro study using cadmium metal was identified. Bacterial tests with cadmium oxide yielded negative results.Data from experimental systems indicate that cadmium, in certain forms, has genotoxic properties and it is reasonable to assume that these properties may also apply to CdO and Cd metal. No other test system using cadmium oxide was located. Most of the located in vitro studies used water-soluble cadmium chloride. Because of the similarity of the candidate substance to cadmium oxide, it is assumed that the candidate substance may be potentially genotoxic similar to cadmium oxide.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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