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EC number: 695-076-0 | CAS number: 1334513-02-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 November 2012-20 December 2012
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.3 (Algal Inhibition test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Propan-2-yl N-[(S)-(pentafluorophenoxy)(phenoxy)-phosphoryl]-L-alanine
- EC Number:
- 695-076-0
- Cas Number:
- 1334513-02-8
- Molecular formula:
- C18H17F5NO5P
- IUPAC Name:
- Propan-2-yl N-[(S)-(pentafluorophenoxy)(phenoxy)-phosphoryl]-L-alanine
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Test item
- Identification: GS-606962
- Description: White powder
- Substance type: organic
- Lot/batch No.: PSI-172(2)-1-1-12001
- Storage condition of test material: room temperature in the dark
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum)
Study design
- Water media type:
- freshwater
- Total exposure duration:
- 72 h
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.079 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- other: 100% v/v saturated solution
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 0.079 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- other: 100% v/v saturated solution
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 50 other: % v/v saturated solution
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- other: 50% v/v saturated solution
- Basis for effect:
- growth rate
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
The effect of the test item on the growth of Pseudokirchneriella subcapitata has been investigated and gave EC50 values on the geometric mean measured test concentrations of greater than 0.079 mg/L. The No Observed Effect Concentration (NOEC) was determined to be 50% v/v saturated solution. Correspondingly the Lowest Observed Effect Concentration (LOEC) was determined to be 100% v/v saturated solution (equivalent to a geometric mean measured test concentration of 0.079 mg/L).- Executive summary:
Introduction
A study was performed to assess the effect of the test item on the growth of the green alga Pseudokirchneriella subcapitata.
The method followed that described in the OECD Guidelines for Testing Chemicals (2006) No 201, "Freshwater Alga and Cyanobacteria, Growth Inhibition Test" referenced as Method C.3 of Commission Regulation (EC) No 761/2009.
Methods
Pre-study solubility work conducted indicated that it was not possible to obtain a testable solution of the the test item using traditional methods of preparation e.g. ultrasonication and high shear mixing.
A pre-study media preparation trial indicated that a dissolved test item concentration of approximately 0.17 mg/L was obtained from a saturated solution method of preparation indicating this to be the limit of water solubility of this item under test conditions.
Following a preliminary range-finding test, Pseudokirchneriella subcapitata was exposed to solutions of the test item at measured concentrations of 6.25, 12.5, 25, 50 and 100% v/v saturated solution (3 replicates flasks per concentrations) for 72 hours, under constant illumination and shaking at a temperature of 24 ± 1°C. The test item solutions were prepared by stirring an excess (50 mg/L) of test item in culture medium using a propeller stirrer at approximately 1500 rpm for 24 hours. After the stirring period any undissolved test item was removed by filtration (0.2 µm Sartorius Sartopore filter, first approximate 2 liters discarded in order to pre-condition the filter) to produce a 100% v/v saturated solution of the test item. The saturated solution was then further diluted as necessary, to provide the remaining test groups.
Samples of the algal population was removed daily and cell concentrations determined for each control and treatment group, using a Coulter Multisizer Partlicle Counter.
Results
Chemical analysis of the 6.25, 12.5, 25 and 50% v/v saturated solution test preparation ast 0 hours showed measured test concentrations of less than the limit of quantitation (LOQ) of the analytical method employed were obtained which was determined to be 0.071 mg/L. A measured concentration of 0.17 mg/L was obtained for the 100% v/v saturated solution test preparation. Analysis of the test preparations at 72 hours showed measured test concentrations of less than the LOQ were obtained for all test preparations indicating that the test item was unstable over the test period.
Given the decline in measured test concentration it was considered appropriate to calculate the results on the geometric mean measured test concentrations.
Exposure of Pseudokirchneriella subcapitata to the test item gave EC50 values based on the geometric mean measured test concentrations of greater than 0.079 mg/L.
The No Observed Effect Concentration (NOEC) was determined to be 50% v/v saturated solution, correspondingly the Lowest Observed Effect Concentration (LOEC) was determined to be 100% v/v saturated solution (equivalent to 0.079 mg/L based on the geometric mean measured test concentrations).
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