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Diss Factsheets
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EC number: 202-442-1 | CAS number: 95-70-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 October 2011 until 16 November 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- sieving
- Type of distribution:
- volumetric distribution
- Key result
- Percentile:
- D50
- Mean:
- > 100 µm
- Remarks on result:
- other: MMD was not actually determined, as > 99.9% of the mass fraction of particles were found to have a diameter > 100 µm (100 µm is the maximum inhalation relevant particle size).(migrated from fields under 'Mass median diameter' as D50 percentile. No source
- No.:
- #1
- Size:
- > 100 µm
- Distribution:
- >= 99.9 %
- No.:
- #2
- Size:
- < 100 µm
- Distribution:
- < 0.1 %
- Conclusions:
- The proportion of test item with a particle size in the inhalable range (i.e. with diameter < 100 µm) has been determined to be less than 0.1 %.
- Executive summary:
The purpose of the study was to determine the particle size distribution of test item 2,5-Diaminotoluene via a method equivalent or similar to OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions). With a screening / sieve method the proportion of test item < 100 µm was determined to be < 0.1%.
The inhalable fraction is defined as the mass fraction of particles which can be inhaled by nose or mouth and are regarded as having a particle size <100 µm. The proportion of test item with a particle size in the inhalable range is insignificant, based on the fact that particles in the range <100 µm was determined to be below 0.1% in the preliminary screening test. Therefore, the results of the screening test obviated the need to carry out further characterisation of the test item by cascade impactor or similar methods.
Reference
Screening test (sieve method)
The results of the sieving procedure are shown in the following table:
Measurement | Result |
Mass of test item transferred to sieve | 10.68g |
Mass of test item passed through sieve | 0.01g |
Proportion of test item <100 µm | <0.1% |
Discussion
The inhalable fraction is defined as the mass fraction of particles which can be inhaled by nose or mouth and are regarded as having a particle size <100µm. The proportion of test item with a particle size in the inhalable range is insignificant, based on the fact that particles in the range <100µm was determined to be below 0.1% in the preliminary screening test. Therefore, the results of the screening test obviated the need to carry out further characterisation of the test item by cascade impactor or similar methods.
Description of key information
The proportion of test item with a particle size in the inhalable range (i.e. with diameter lower than 100 µm) has been determined to be less than 0.1 %.
Additional information
The particle size distribution of test item 2-methyl-p-phenylenediamine was determined via a method equivalent or similar to OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions). With a screening / sieve method the proportion of test item being of inhalable particle size < 100 µm was determined to be < 0.1%.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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