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EC number: 279-399-0 | CAS number: 80118-06-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 06, 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was performed prior to the OECD Test Guideline No. 401 but the protocol is similar to that guidance.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: US FHSA CFR 1500.3 (HSLA)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- (environmental conditions not reported)
- Principles of method if other than guideline:
- Acute gavage administration to rats.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1,3-dimethylbut-3-enyl isobutyrate
- EC Number:
- 279-399-0
- EC Name:
- 1,3-dimethylbut-3-enyl isobutyrate
- Cas Number:
- 80118-06-5
- Molecular formula:
- C10H18O2
- IUPAC Name:
- 4-methylpent-4-en-2-yl 2-methylpropanoate
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): MT-102.Methylpentenol isobutyrate
- Physical state: Clear colorless liquid
- Density: 0.90 g/mL
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Blue Spruce Farms, Inc., Altamont, NY.
- Weight at study initiation: 183-225 g
- Fasting period before study: Animals were fasted overnight (ca. 18 h) prior to oral intubation.
- Housing: Animals were housed in wire mesh bottom cages in rooms with temperature control.
- Acclimation period: ca. 2 weeks
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: no data
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: Animals were observed three times a day on the day of dosing, twice daily on Day 1 and once daily for the remainder of the study. All gross or visible toxic or pharmacological effects were recorded.
- Necropsy of survivors performed: no; all animals that died during the study were subjected to a complete gross necropsy. - Statistics:
- None
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: one of ten animals died on day 2 post dosing
- Mortality:
- One of ten animals died on day 2 post dosing. The 95 % confidence interval for this 10 % rate of mortality is 0 to 40 % when the test material was administered to rats orally at a level of 5000 mg/kg bw.
- Clinical signs:
- other: - Diarrhea was observed in 3/5 females; ataxia in 4/5 male and 5/5 female animals; decreased activity in all animals
- Gross pathology:
- - No abnormalities were noted at necropsy except pale lungs, mottled liver, pale kidneys and small & granular spleen were observed in one male.
- Other findings:
- None
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Oral LD50 Combined > 5000 mg/kg bw
- Executive summary:
In an acute oral toxicity study (limit test) performed similarly to OECD Guideline No. 401 and in compliance with GLP, groups (5/sex/dose) of Sprague-Dawley rats were given a single oral (gavage) dose of test material at 5000 mg/kg bw. Animals were then observed for mortality, clinical signs and bodyweights for 14 days and all the animals that died during the study were sacrificed for macroscopic examination.
One of ten animals died on day 2 post dosing. Diarrhea was observed in 3/5 females; ataxia in 4/5 male and 5/5 female animals; decreased activity in all animals. Surviving animals showed expected gains in bodyweight over the 14-day study period. No abnormalities were noted at necropsy except pale lungs, mottled liver, pale kidneys and small & granular spleen were observed in one male.
Oral LD50 Combined > 5000 mg/kg bw.
Under the test conditions, the test material is not classified for acute oral toxicity according to the annex VI of the Regulation EC No. 1272/2008 (CLP).
This study is considered as acceptable and satisfies the requirement for acute oral toxicity endpoint.
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