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EC number: 606-790-9 | CAS number: 215247-95-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- cytotoxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study performed under GLP, no OECD guideline applicable
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
- Reference Type:
- other:
- Title:
- Final toxicology review of carbazole violet (CI Pigment Violet 23) for use as a colorant in contact lenses
- Author:
- Additives Evaluation Branch (HFF-158), Division of Food and Color Additives, Center for Food Safety and Applied Nutrition, Department of Health and Human Services
- Report date:
- 1988
Materials and methods
- Principles of method if other than guideline:
- In vitro cytotoxicity on monolayer of L-929 mouse fibroblast cells
- GLP compliance:
- yes
- Type of method:
- in vitro
- Endpoint addressed:
- skin irritation / corrosion
- eye irritation
Test material
- Reference substance name:
- 2,20-dichloro-13,31-diethyl-4,22-dioxa-13,18,31,36-tetraazanonacyclo[19.15.0.0³,¹⁹.0⁵,¹⁷.0⁶,¹⁴.0⁷,¹².0²³,³⁵.0²⁴,³².0²⁵,³⁰]hexatriaconta-1(36),2,5,7(12),8,10,14,16,18,20,23(35),24(32),25,27,29,33-hexadecaene
- EC Number:
- 606-790-9
- Cas Number:
- 215247-95-3
- Molecular formula:
- C34H22Cl2N4O2
- IUPAC Name:
- 2,20-dichloro-13,31-diethyl-4,22-dioxa-13,18,31,36-tetraazanonacyclo[19.15.0.0³,¹⁹.0⁵,¹⁷.0⁶,¹⁴.0⁷,¹².0²³,³⁵.0²⁴,³².0²⁵,³⁰]hexatriaconta-1(36),2,5,7(12),8,10,14,16,18,20,23(35),24(32),25,27,29,33-hexadecaene
- Test material form:
- solid: particulate/powder
Constituent 1
Administration / exposure
- Route of administration:
- other: in vitro exposure of cell line via the culture medium
- Vehicle:
- other: MEM cell culture medium
- Duration of treatment / exposure:
- 24 hours
- Frequency of treatment:
- one treatment
- Post exposure period:
- not relevant
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.1 g in 2 ml MEM cell culture medium
Basis:
nominal conc.
- Details on study design:
- A confluent monolayer of L-929 Mouse Fibroblast cells was used. Monolayers were washed with Calcium and Magnesium Free Phosphate buffered saline and 2 ml of 5% MEM (without neutral red) and the test sample (0.1 g ) and controls (amount not given) were added to the cultures.
Test Materials:
- Carbazole Violet (neat powder) Pigment,
- USP Negative Control Plastic
- Positive Control latex, P-11102*
Examinations
- Examinations:
- After a 24 hour incubation at 37 C the cultures were observed microscopically for cell lysis. Observations were scored as nontoxic, no change in cell
morphology, or toxic, death and degeneration of cells observed (no zones of lysis measured).
Results and discussion
- Details on results:
- A single culture exposed to 0.1 g of carbazole violet and a single negative control culture were scored as nontoxic.
The positive control was scored as toxic, cells around the control material were lysed.
Applicant's summary and conclusion
- Conclusions:
- In a in vitro cytotoxicity study, Carbazole violet (Pigment Violet 23) at a concentration of 50 mg/ml was not cytotoxic to cultured mammalian cells (L929 mouse fibroblasts) when incubated for 24 hours.
- Executive summary:
In a in vitro cytotoxicity study, Carbazole violet (Pigment Violet 23) at a concentration of 50 mg/ml was not cytotoxic to cultured mammalian cells (L929 mouse fibroblasts) when incubated for 24 hours.
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