Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 229-319-5 | CAS number: 6471-78-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Low concern for acute toxicity of 5-methoxy-2-methylsulphanilic acid based on read-across with similar substances.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- Data from reliable sources (SIDS dossier of 4-aminotoluene-3-sulfonic acid and ECHA website for sulphanilic acid)
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- Data from reliable sources (ECHA website)
Additional information
No data are available for acute toxicity of 5-methoxy-2-methylsulphanilic acid.
A low acute toxicity for 5-methoxy-2-methylsulphanilic acid was expected based on read-across data with 2 substances of similar structure (more similar substance: 4-aminotoluene-3-sulfonic acid; less similar substance: sulphanilic acid).
For justification of read-across see attachment document in section 13.
Oral exposure:
No data are available for acute oral toxicity of 5-methoxy-2-methylsulphanilic acid. The presumable absence of classification for oral acute toxicity regarding 5-methoxy-2-methylsulphanilic acid is supported by read-across with two compounds of similar structure.
As reported in SIDS Dossier of 4-aminotoluene-3-sulfonic acid approved at SIAM 16 (27 -30 May 2003) with reference to Ministry of Health & Welfare, Japan (1996): Toxicity Testing Reports of Environmental Chemicals, vol.4 p.99-106, "Twenty-eight-day Repeat Dose Oral Toxicity Test of 2-Amino-5-methylbenzenesulfonic acid in Rats" from the outcome of a single dose administration reported in a preliminary examination of a 28-Day Repeat Dose Toxicity study (OECD TG407), the oral LD50 in rats is considered to be greater than 2000 mg/kg in both sexes. Also from information from ECHA website with reference to an experimental study of 2010 regarding sulphanilic acid LD50 rat greater than 2000 mg/kg is reported.
Inhalation exposure:
No data are available for inhalation toxicity of 5-methoxy-2-methylsulphanilic acid. No read-across is possible with substances with similar structure due to lack of data.
Dermal exposure:
No data are available for dermal toxicity of 5-methoxy-2-methylsulphanilic acid. For a similar compound (sulphanilic acid) on ECHA website with reference to experimental study of 2010 LD50 dermal rat greater than 2000 mg/kg is reported.
The public ECHA database contains data that are proprietary and cannot be used without the formal consent of the owner. In this summary, some of them have been used for precautionary purposes and for the benefit of the human health and the environment. Those data are not necessary for the registration of the target substance which is used exclusively as isolated and transported intermediate, but they can be very helpful for a better definition of the (eco) toxicological property of the substance. No other use and no commercial advantage will derive from the use of those data.
Justification for selection of acute toxicity – oral endpoint
Read across with substances with similar structures.
Justification for selection of acute toxicity – dermal endpoint
Read across with substances with similar structures.
Justification for classification or non-classification
According to CLP Regulation (EC n. 1272/2008), 5-methoxy-2-methylsulphanilic acid should be not classified for acute toxicity : no data are available for the substance but from read-across with 4-aminotoluene-3-sulfonic acid and sulphanilic acid there is no reason of concern.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.