Registration Dossier
Registration Dossier
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EC number: 202-085-1 | CAS number: 91-63-4
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
As reported in Summary report of Toxicological Literature for Methylquinolines, NTP,2002 with reference to Sengoku et all, Mutat. Res. 216:375 (1989), 2-methylquinoline shows a certain mutagenic effect but it has got the weakest mutagenicity among the methylquinoline. Different bacteria studies of genotoxicity are reported in Summary report of Toxicological Literature for Methylquinolines, NTP,2002, some with positive effects other with negative effects:
- positive effects at concentrations of 100 to 600 μg (0.708 to 4.19 μmol) per plate in S. typhimurium strain TA100 with metabolic activation (see Dong et all, Carcinogenesis 3:97108, 1978- mentioned also in EFSA Journal (2008) 792,1-63);
- positive effects in S. typhimurium (strain n.p.) at 2 μmol (300 μg) per plate in the absence of metabolic activation (see Takahashi et all,Chem. Pharm. Bull. (Tokyo)36(11):4630-4633, 1988-mentioned also in EFSA Journal (2008) 792,1-63);
- negative effects when tested at concentrations of 50 to 500 μg (0.35 to 3.5 μmol) per plate in S. typhimurium strains TA1535, TA1537, TA1538, TA98 and TA100 with and without metabolic activation (see Boden et all, J. Natl. Cancer Inst. 57(4):921-924, 1976 mentioned also in EFSA Journal (2008) 792,1-63);
- negative effects at 7mM (1002.33 μg/mL) in S. typhimuriumstrain TM677 with metabolic activation (see Phillips Petroleum, Personal authors Kaden,Mutagenicity of Kerosene Soot and Associated Polycyclic Aromatic Hydrocarbons to Salmonella typhimurium with cover letter dated 08/24/92. Microfiche No. OTS0555325; document No. 8EHQ-0992-10720 mentioned also in EFSA Journal (2008) 792,1-63);
In EFSA Journal (2008) 792,1-63 a negative effect is reported also for Unscheduled DNA synthesis test on rat hepatocytes at concentration of 0.5 and 1 mM (see La Voie et all, Carcinogenesis 12(2), 217-220., 1991).
Justification for selection of genetic toxicity endpoint
Data from Summary report of Toxicological Literature for Methylquinolines, NTP,2002
Short description of key information:
2-methylquinoline has got a weak genotoxicity (weakest mutagenicity among the methylquinolines).
Endpoint Conclusion: Adverse effect observed (positive)
Justification for classification or non-classification
From different studies reported in Summary report of Toxicological Literature for Methylquinolines, NTP,2002 and in EFSA Journal (2008) 792,1-63 (see section discussion above) there are some reasons of concern regarding genotoxicity of 2-methylquinoline. Based on these studies the classification H341 (Suspected of causing genetic defects ; germ cell mutageny cat.2) is proposed for 2-methylquinoline according to CLP Regulation (EC n.1272/2008).
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